Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

Ling Luo*, Hironori Uehara, Xiaohui Zhang, Subrata K. Das, Thomas Olsen, Derick Holt, Jacquelyn M. Simonis, Kyle Jackman, Nirbhai Singh, Tadashi R. Miya, Wei Huang, Faisal Ahmed, Ana Bastos-Carvalho, Yun Zheng Le, Christina Mamalis, Vince A. Chiodo, William W. Hauswirth, Judit Baffi, Pedro M. Lacal, Angela OrecchiaNapoleone Ferrara, Guangping Gao, Kim Young-hee, Yingbin Fu, Leah Owen, Romulo Albuquerque, Wolfgang Baehr, Kirk Thomas, Dean Y. Li, Kakarla V. Chalam, Masabumi Shibuya, Salvatore Grisanti, David J. Wilson, Jayakrishna Ambati, Balamurali K. Ambati

*Corresponding author for this work
52 Citations (Scopus)


Optimal phototransduction requires separation of the avascular photoreceptor layer from the adjacent vascularized inner retina and choroid. Breakdown of peri-photoreceptor vascular demarcation leads to retinal angiomatous proliferation or choroidal neovascularization, two variants of vascular invasion of the photoreceptor layer in age-related macular degeneration (AMD), the leading cause of irreversible blindness in industrialized nations. Here we show that sFLT-1, an endogenous inhibitor of vascular endothelial growth factor A (VEGF-A), is synthesized by photoreceptors and retinal pigment epithelium (RPE), and is decreased in human AMD. Suppression of sFLT-1 by antibodies, adeno-associated virus-mediated RNA interference, or Cre/lox-mediated gene ablation either in the photoreceptor layer or RPE frees VEGF-A and abolishes photoreceptor avascularity. These findings help explain the vascular zoning of the retina, which is critical for vision, and advance two transgenic murine models of AMD with spontaneous vascular invasion early in life.

Original languageEnglish
Article numbere00324
Issue number2
Publication statusPublished - 18.06.2013

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


Dive into the research topics of 'Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1'. Together they form a unique fingerprint.

Cite this