PHES scores have limited impact on the risk of overt HE in patients with minimal HE

Simon Johannes Gairing; Chiara Mangini; Lisa Zarantonello; Elise Jonasson; Sven Danneberg; Philippe Sultanik; Peter Robert Galle; Stefania Gioia; Joachim Labenz; Anna S. Lok; Jens Uwe Marquardt; Mette Munk Lauridsen; Patricia P. Bloom; Dominique Thabut; Silvia Nardelli; Sara Montagnese; Christian Labenz

doi:10.1097/HC9.0000000000000438

PHES scores have limited impact on the risk of overt HE in patients with minimal HE

Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Elise Jonasson, Sven Danneberg, Philippe Sultanik, Peter Robert Galle, Stefania Gioia, Joachim Labenz, Anna S. Lok, Jens Uwe Marquardt, Mette Munk Lauridsen, Patricia P. Bloom, Dominique Thabut, Silvia Nardelli, Sara Montagnese, Christian Labenz^*

^*Corresponding author for this work

Clinic of Internal Medicine I

Abstract

Background: Minimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent OHE. It remains unclear if there is a stepwise increase in OHE risk with worse PHES results. Methods: In this multicenter study, patients with minimal hepatic encephalopathy, as defined by abnormal PHES, were followed for OHE development. Results: In all, 207 patients were included. There was no stepwise increase in OHE risk with worse PHES results. Conclusions: Abnormal PHES is associated with a higher OHE risk, but we found no stepwise increase in OHE risk with worse PHES results below the established cutoff. 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

Original language	English
Article number	10.1097/HC9.0000000000000438
Journal	Hepatology Communications
Volume	8
Issue number	5
DOIs	https://doi.org/10.1097/HC9.0000000000000438
Publication status	Published - 03.05.2024

Funding

Funders	Funder number
Vedanta Biosciences
Deutsche Forschungsgemeinschaft
Dr. Rolf M. Schwiete Stiftung

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1097/HC9.0000000000000438

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Gairing, S. J., Mangini, C., Zarantonello, L., Jonasson, E., Danneberg, S., Sultanik, P., Galle, P. R., Gioia, S., Labenz, J., Lok, A. S., Marquardt, J. U., Lauridsen, M. M., Bloom, P. P., Thabut, D., Nardelli, S., Montagnese, S., & Labenz, C. (2024). PHES scores have limited impact on the risk of overt HE in patients with minimal HE. Hepatology Communications, 8(5), Article 10.1097/HC9.0000000000000438. https://doi.org/10.1097/HC9.0000000000000438

@article{93a11d7031684a0ab586e4085e2fc27a,

title = "PHES scores have limited impact on the risk of overt HE in patients with minimal HE",

abstract = "Background: Minimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent OHE. It remains unclear if there is a stepwise increase in OHE risk with worse PHES results. Methods: In this multicenter study, patients with minimal hepatic encephalopathy, as defined by abnormal PHES, were followed for OHE development. Results: In all, 207 patients were included. There was no stepwise increase in OHE risk with worse PHES results. Conclusions: Abnormal PHES is associated with a higher OHE risk, but we found no stepwise increase in OHE risk with worse PHES results below the established cutoff. 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.",

author = "Gairing, \{Simon Johannes\} and Chiara Mangini and Lisa Zarantonello and Elise Jonasson and Sven Danneberg and Philippe Sultanik and Galle, \{Peter Robert\} and Stefania Gioia and Joachim Labenz and Lok, \{Anna S.\} and Marquardt, \{Jens Uwe\} and Lauridsen, \{Mette Munk\} and Bloom, \{Patricia P.\} and Dominique Thabut and Silvia Nardelli and Sara Montagnese and Christian Labenz",

year = "2024",

month = may,

day = "3",

doi = "10.1097/HC9.0000000000000438",

language = "English",

volume = "8",

journal = "Hepatology Communications",

issn = "2471-254X",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

Gairing, SJ, Mangini, C, Zarantonello, L, Jonasson, E, Danneberg, S, Sultanik, P, Galle, PR, Gioia, S, Labenz, J, Lok, AS, Marquardt, JU, Lauridsen, MM, Bloom, PP, Thabut, D, Nardelli, S, Montagnese, S & Labenz, C 2024, 'PHES scores have limited impact on the risk of overt HE in patients with minimal HE', Hepatology Communications, vol. 8, no. 5, 10.1097/HC9.0000000000000438. https://doi.org/10.1097/HC9.0000000000000438

TY - JOUR

T1 - PHES scores have limited impact on the risk of overt HE in patients with minimal HE

AU - Gairing, Simon Johannes

AU - Mangini, Chiara

AU - Zarantonello, Lisa

AU - Jonasson, Elise

AU - Danneberg, Sven

AU - Sultanik, Philippe

AU - Galle, Peter Robert

AU - Gioia, Stefania

AU - Labenz, Joachim

AU - Lok, Anna S.

AU - Marquardt, Jens Uwe

AU - Lauridsen, Mette Munk

AU - Bloom, Patricia P.

AU - Thabut, Dominique

AU - Nardelli, Silvia

AU - Montagnese, Sara

AU - Labenz, Christian

PY - 2024/5/3

Y1 - 2024/5/3

N2 - Background: Minimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent OHE. It remains unclear if there is a stepwise increase in OHE risk with worse PHES results. Methods: In this multicenter study, patients with minimal hepatic encephalopathy, as defined by abnormal PHES, were followed for OHE development. Results: In all, 207 patients were included. There was no stepwise increase in OHE risk with worse PHES results. Conclusions: Abnormal PHES is associated with a higher OHE risk, but we found no stepwise increase in OHE risk with worse PHES results below the established cutoff. 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

AB - Background: Minimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent OHE. It remains unclear if there is a stepwise increase in OHE risk with worse PHES results. Methods: In this multicenter study, patients with minimal hepatic encephalopathy, as defined by abnormal PHES, were followed for OHE development. Results: In all, 207 patients were included. There was no stepwise increase in OHE risk with worse PHES results. Conclusions: Abnormal PHES is associated with a higher OHE risk, but we found no stepwise increase in OHE risk with worse PHES results below the established cutoff. 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

UR - https://www.scopus.com/pages/publications/85204901277

U2 - 10.1097/HC9.0000000000000438

DO - 10.1097/HC9.0000000000000438

M3 - Journal articles

C2 - 38701395

AN - SCOPUS:85204901277

SN - 2471-254X

VL - 8

JO - Hepatology Communications

JF - Hepatology Communications

IS - 5

M1 - 10.1097/HC9.0000000000000438

ER -

PHES scores have limited impact on the risk of overt HE in patients with minimal HE

Abstract

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UN SDGs

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