Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue

Sazgar Burhan, Nicolas Detrez, Katharina Rewerts, Paul Strenge, Steffen Buschschlüter, Jessica Kren, Christian Hagel, Matteo Mario Bonsanto, Ralf Brinkmann, Robert Huber


During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm’s reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm’s dependability.

Original languageEnglish
JournalBiomed. Opt. Express
Issue number2
Pages (from-to)1038-1058
Number of pages21
Publication statusPublished - 10.02.2024

Research Areas and Centers

  • Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

  • 205-32 Medical Physics, Biomedical Engineering
  • 206-07 Clinical Neurology Neurosurgery and Neuroradiology

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