Perspectives in allergen immunotherapy: 2019 and beyond

Oliver Pfaar*, Ioana Agache, Frédéric de Blay, Sergio Bonini, Adam M. Chaker, Stephen R. Durham, Radoslaw Gawlik, Peter W. Hellings, Marek Jutel, Jörg Kleine-Tebbe, Ludger Klimek, Matthias V. Kopp, Andreas Nandy, Ronald L. Rabin, Ronald van Ree, Harald Renz, Graham Roberts, Anne Marie Salapatek, Carsten B. Schmidt-Weber, Mohamed H. ShamjiGunter J. Sturm, J. Christian Virchow, Ulrich Wahn, Christoph Willers, Petra Zieglmayer, Cezmi A. Akdis

*Corresponding author for this work
21 Citations (Scopus)


The seventh “Future of the Allergists and Specific Immunotherapy (FASIT)” workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following: (a) Biomarkers for AIT and allergic asthma; (b) visions for the future of AIT; (c) progress and data for AIT in asthma and the updates of GINA and EAACI Asthma Guidelines (separated for house dust mite SCIT, SLIT tablets and SLIT drops; patient populations) including a review of clinically relevant endpoints in AIT studies in asthma; (d) regulatory prerequisites such as the “Therapy Allergen Ordinance” in Germany; (e) optimization of trial design in AIT clinical research; (f) challenges planning and conducting phase III (field) studies and the future role of Allergen Exposure Chambers (AEC) in AIT product development from the regulatory point of view. We report a summary of panel discussions of all six domains and highlight unmet needs and possible solutions for the future.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue numberS108
Pages (from-to)3-25
Number of pages23
Publication statusPublished - 01.12.2019


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