Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer

Dirk Rades; Steven E. Schild; Amira Bajrovic; Stefan Janssen; Tobias Bartscht

Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer

Dirk Rades, Steven E. Schild, Amira Bajrovic, Stefan Janssen, Tobias Bartscht

Abstract

AIM: To facilitate personalization of radiotherapy (RT) for elderly patients with epidural cord compression (ECC) from gastric cancer.

PATIENTS AND METHODS: Several factors were analyzed for survival in 20 elderly patients including age, gender, time period from gastric cancer diagnosis to ECC, metastatic spread, additional osseous lesions, vertebral bodies afflicted by ECC, ambulatory function, dynamic of motor dysfunction, performance status and RT fractionation.

RESULTS: Four factors had a significant influence on survival: metastatic spread (p<0.001), ambulatory function (p=0.001), dynamics of motor dysfunction (p=0.002) and performance status (p=0.003). Points were assigned according to factors present for each patient. To avoid confounding variables, performance status was not incorporated into the scoring system. Based on 3-month survival rates, patients were divided into four groups according to the total score: 6, 12-13, 19 and 26 points. Three-month survival rates for these groups were 0%, 50%, 75% and 100%, respectively (p<0.001).

CONCLUSION: This score is of great assistance when assigning the appropriate RT approach to an elderly patient with ECC from gastric cancer.

Original language	English
Journal	In vivo (Athens, Greece)
Volume	30
Issue number	1
Pages (from-to)	69-72
Number of pages	4
ISSN	0258-851X
Publication status	Published - 01.01.2016

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@article{9e227057780d45e3b167e1ad2228312b,

title = "Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer",

abstract = "AIM: To facilitate personalization of radiotherapy (RT) for elderly patients with epidural cord compression (ECC) from gastric cancer.PATIENTS AND METHODS: Several factors were analyzed for survival in 20 elderly patients including age, gender, time period from gastric cancer diagnosis to ECC, metastatic spread, additional osseous lesions, vertebral bodies afflicted by ECC, ambulatory function, dynamic of motor dysfunction, performance status and RT fractionation.RESULTS: Four factors had a significant influence on survival: metastatic spread (p<0.001), ambulatory function (p=0.001), dynamics of motor dysfunction (p=0.002) and performance status (p=0.003). Points were assigned according to factors present for each patient. To avoid confounding variables, performance status was not incorporated into the scoring system. Based on 3-month survival rates, patients were divided into four groups according to the total score: 6, 12-13, 19 and 26 points. Three-month survival rates for these groups were 0\%, 50\%, 75\% and 100\%, respectively (p<0.001).CONCLUSION: This score is of great assistance when assigning the appropriate RT approach to an elderly patient with ECC from gastric cancer.",

author = "Dirk Rades and Schild, \{Steven E.\} and Amira Bajrovic and Stefan Janssen and Tobias Bartscht",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

year = "2016",

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T1 - Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer

AU - Rades, Dirk

AU - Schild, Steven E.

AU - Bajrovic, Amira

AU - Janssen, Stefan

AU - Bartscht, Tobias

N1 - Publisher Copyright: Copyright © 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2016/1/1

Y1 - 2016/1/1

N2 - AIM: To facilitate personalization of radiotherapy (RT) for elderly patients with epidural cord compression (ECC) from gastric cancer.PATIENTS AND METHODS: Several factors were analyzed for survival in 20 elderly patients including age, gender, time period from gastric cancer diagnosis to ECC, metastatic spread, additional osseous lesions, vertebral bodies afflicted by ECC, ambulatory function, dynamic of motor dysfunction, performance status and RT fractionation.RESULTS: Four factors had a significant influence on survival: metastatic spread (p<0.001), ambulatory function (p=0.001), dynamics of motor dysfunction (p=0.002) and performance status (p=0.003). Points were assigned according to factors present for each patient. To avoid confounding variables, performance status was not incorporated into the scoring system. Based on 3-month survival rates, patients were divided into four groups according to the total score: 6, 12-13, 19 and 26 points. Three-month survival rates for these groups were 0%, 50%, 75% and 100%, respectively (p<0.001).CONCLUSION: This score is of great assistance when assigning the appropriate RT approach to an elderly patient with ECC from gastric cancer.

AB - AIM: To facilitate personalization of radiotherapy (RT) for elderly patients with epidural cord compression (ECC) from gastric cancer.PATIENTS AND METHODS: Several factors were analyzed for survival in 20 elderly patients including age, gender, time period from gastric cancer diagnosis to ECC, metastatic spread, additional osseous lesions, vertebral bodies afflicted by ECC, ambulatory function, dynamic of motor dysfunction, performance status and RT fractionation.RESULTS: Four factors had a significant influence on survival: metastatic spread (p<0.001), ambulatory function (p=0.001), dynamics of motor dysfunction (p=0.002) and performance status (p=0.003). Points were assigned according to factors present for each patient. To avoid confounding variables, performance status was not incorporated into the scoring system. Based on 3-month survival rates, patients were divided into four groups according to the total score: 6, 12-13, 19 and 26 points. Three-month survival rates for these groups were 0%, 50%, 75% and 100%, respectively (p<0.001).CONCLUSION: This score is of great assistance when assigning the appropriate RT approach to an elderly patient with ECC from gastric cancer.

UR - https://www.scopus.com/pages/publications/84989204631

M3 - Journal articles

C2 - 26709131

AN - SCOPUS:84989204631

SN - 0258-851X

VL - 30

SP - 69

EP - 72

JO - In vivo (Athens, Greece)

JF - In vivo (Athens, Greece)

IS - 1

ER -

Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer

Abstract

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