TY - JOUR
T1 - Personalized Estimates of Brain Structural Variability in Individuals with Early Psychosis
AU - Antoniades, Mathilde
AU - Haas, Shalaila S.
AU - Modabbernia, Amirhossein
AU - Bykowsky, Oleg
AU - Frangou, Sophia
AU - Borgwardt, Stefan
AU - Schmidt, André
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Background: Early psychosis in first-episode psychosis (FEP) and clinical high-risk (CHR) individuals has been associated with alterations in mean regional measures of brain morphology. Examination of variability in brain morphology could assist in quantifying the degree of brain structural heterogeneity in clinical relative to healthy control (HC) samples. Methods: Structural magnetic resonance imaging data were obtained from CHR (n = 71), FEP (n = 72), and HC individuals (n = 55). Regional brain variability in cortical thickness (CT), surface area (SA), and subcortical volume (SV) was assessed with the coefficient of variation (CV). Furthermore, the person-based similarity index (PBSI) was employed to quantify the similarity of CT, SA, and SV profile of each individual to others within the same diagnostic group. Normative modeling of the PBSI-CT, PBSI-SA, and PBSI-SV was used to identify CHR and FEP individuals whose scores deviated markedly from those of the healthy individuals. Results: There was no effect of diagnosis on the CV for any regional measure (P >. 38). CHR and FEP individuals differed significantly from the HC group in terms of PBSI-CT (P <. 0001), PBSI-SA (P <. 0001), and PBSI-SV (P =. 01). In the clinical groups, normative modeling identified 32 (22%) individuals with deviant PBSI-CT, 12 (8.4%) with deviant PBSI-SA, and 21 (15%) with deviant PBSI-SV; differences of small effect size indicated that individuals with deviant PBSI scores had lower IQ and higher psychopathology. Conclusions: Examination of brain structural variability in early psychosis indicated heterogeneity at the level of individual profiles and encourages further large-scale examination to identify individuals that deviate markedly from normative reference data.
AB - Background: Early psychosis in first-episode psychosis (FEP) and clinical high-risk (CHR) individuals has been associated with alterations in mean regional measures of brain morphology. Examination of variability in brain morphology could assist in quantifying the degree of brain structural heterogeneity in clinical relative to healthy control (HC) samples. Methods: Structural magnetic resonance imaging data were obtained from CHR (n = 71), FEP (n = 72), and HC individuals (n = 55). Regional brain variability in cortical thickness (CT), surface area (SA), and subcortical volume (SV) was assessed with the coefficient of variation (CV). Furthermore, the person-based similarity index (PBSI) was employed to quantify the similarity of CT, SA, and SV profile of each individual to others within the same diagnostic group. Normative modeling of the PBSI-CT, PBSI-SA, and PBSI-SV was used to identify CHR and FEP individuals whose scores deviated markedly from those of the healthy individuals. Results: There was no effect of diagnosis on the CV for any regional measure (P >. 38). CHR and FEP individuals differed significantly from the HC group in terms of PBSI-CT (P <. 0001), PBSI-SA (P <. 0001), and PBSI-SV (P =. 01). In the clinical groups, normative modeling identified 32 (22%) individuals with deviant PBSI-CT, 12 (8.4%) with deviant PBSI-SA, and 21 (15%) with deviant PBSI-SV; differences of small effect size indicated that individuals with deviant PBSI scores had lower IQ and higher psychopathology. Conclusions: Examination of brain structural variability in early psychosis indicated heterogeneity at the level of individual profiles and encourages further large-scale examination to identify individuals that deviate markedly from normative reference data.
UR - http://www.scopus.com/inward/record.url?scp=85111043178&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbab005
DO - 10.1093/schbul/sbab005
M3 - Journal articles
C2 - 33547470
AN - SCOPUS:85111043178
VL - 47
SP - 1029
EP - 1038
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
SN - 0586-7614
IS - 4
ER -