Personality traits influence the effects of diazepam and caffeine on CNV magnitude

Thomas Frank Münte; Hans Jochen Heinze; Helmut Künkel; Michael Scholz

doi:10.1159/000118111

Personality traits influence the effects of diazepam and caffeine on CNV magnitude

Thomas Frank Münte, Hans Jochen Heinze^*, Helmut Künkel, Michael Scholz

^*Corresponding author for this work

8 Citations (Scopus)

Abstract

The time course of the effects of caffeine (200 mg), diazepam (8 mg) and placebo on CNV magnitude, reaction time and state of mood was investigated in normal volunteers using a double-foreperiod paradigm. CNV changes were quantified by means of a linear robust fitting technique. In general, a reduction of amplitude was found for diazepam and an enhancement followed by a suppression in the caffeine condition. Emotional lability of the subjects, as measured by the Freiburg Personality Inventory was shown to strongly influence the nature and time course of these drug effects. Differential drug responses are discussed in terms of the attention arousal model.

Original language	English
Journal	Neuropsychobiology
Volume	12
Issue number	1
Pages (from-to)	60-67
Number of pages	8
ISSN	0302-282X
DOIs	https://doi.org/10.1159/000118111
Publication status	Published - 01.01.1984

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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abstract = "The time course of the effects of caffeine (200 mg), diazepam (8 mg) and placebo on CNV magnitude, reaction time and state of mood was investigated in normal volunteers using a double-foreperiod paradigm. CNV changes were quantified by means of a linear robust fitting technique. In general, a reduction of amplitude was found for diazepam and an enhancement followed by a suppression in the caffeine condition. Emotional lability of the subjects, as measured by the Freiburg Personality Inventory was shown to strongly influence the nature and time course of these drug effects. Differential drug responses are discussed in terms of the attention arousal model.",

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AB - The time course of the effects of caffeine (200 mg), diazepam (8 mg) and placebo on CNV magnitude, reaction time and state of mood was investigated in normal volunteers using a double-foreperiod paradigm. CNV changes were quantified by means of a linear robust fitting technique. In general, a reduction of amplitude was found for diazepam and an enhancement followed by a suppression in the caffeine condition. Emotional lability of the subjects, as measured by the Freiburg Personality Inventory was shown to strongly influence the nature and time course of these drug effects. Differential drug responses are discussed in terms of the attention arousal model.

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Personality traits influence the effects of diazepam and caffeine on CNV magnitude

Abstract

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