Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review

Luca Tagliaferri; Francesco Bussu; Bruno Fionda; Francesco Catucci; Mario Rigante; Maria Antonietta Gambacorta; Rosa Autorino; Gian Carlo Mattiucci; Francesco Miccichè; Elisa Placidi; Mario Balducci; Jacopo Galli; Gaetano Paludetti; György Kovacs; Vincenzo Valentini

doi:10.5301/tj.5000614

Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review

Luca Tagliaferri, Francesco Bussu^*, Bruno Fionda, Francesco Catucci, Mario Rigante, Maria Antonietta Gambacorta, Rosa Autorino, Gian Carlo Mattiucci, Francesco Miccichè, Elisa Placidi, Mario Balducci, Jacopo Galli, Gaetano Paludetti, György Kovacs, Vincenzo Valentini

^*Corresponding author for this work

Clinic of Radiotherapy

Catholic University of the Sacred Heart

38 Citations (Scopus)

Abstract

Aim: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. Materials and methods: Patients treated with prior radiation doses > 65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library. Results: Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review. Conclusions: IMBT could play an important role in the retreatment of recurrent head and neck cancer.

Original language	English
Journal	Tumori
Volume	103
Issue number	6
Pages (from-to)	516-524
Number of pages	9
ISSN	0300-8916
DOIs	https://doi.org/10.5301/tj.5000614
Publication status	Published - 03.08.2017

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Tagliaferri, L., Bussu, F., Fionda, B., Catucci, F., Rigante, M., Gambacorta, M. A., Autorino, R., Mattiucci, G. C., Miccichè, F., Placidi, E., Balducci, M., Galli, J., Paludetti, G., Kovacs, G., & Valentini, V. (2017). Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review. Tumori, 103(6), 516-524. https://doi.org/10.5301/tj.5000614

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title = "Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review",

abstract = "Aim: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. Materials and methods: Patients treated with prior radiation doses > 65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library. Results: Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review. Conclusions: IMBT could play an important role in the retreatment of recurrent head and neck cancer.",

author = "Luca Tagliaferri and Francesco Bussu and Bruno Fionda and Francesco Catucci and Mario Rigante and Gambacorta, \{Maria Antonietta\} and Rosa Autorino and Mattiucci, \{Gian Carlo\} and Francesco Miccich{\`e} and Elisa Placidi and Mario Balducci and Jacopo Galli and Gaetano Paludetti and Gy{\"o}rgy Kovacs and Vincenzo Valentini",

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doi = "10.5301/tj.5000614",

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Tagliaferri, L, Bussu, F, Fionda, B, Catucci, F, Rigante, M, Gambacorta, MA, Autorino, R, Mattiucci, GC, Miccichè, F, Placidi, E, Balducci, M, Galli, J, Paludetti, G, Kovacs, G & Valentini, V 2017, 'Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review', Tumori, vol. 103, no. 6, pp. 516-524. https://doi.org/10.5301/tj.5000614

TY - JOUR

T1 - Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review

AU - Tagliaferri, Luca

AU - Bussu, Francesco

AU - Fionda, Bruno

AU - Catucci, Francesco

AU - Rigante, Mario

AU - Gambacorta, Maria Antonietta

AU - Autorino, Rosa

AU - Mattiucci, Gian Carlo

AU - Miccichè, Francesco

AU - Placidi, Elisa

AU - Balducci, Mario

AU - Galli, Jacopo

AU - Paludetti, Gaetano

AU - Kovacs, György

AU - Valentini, Vincenzo

PY - 2017/8/3

Y1 - 2017/8/3

N2 - Aim: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. Materials and methods: Patients treated with prior radiation doses > 65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library. Results: Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review. Conclusions: IMBT could play an important role in the retreatment of recurrent head and neck cancer.

AB - Aim: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. Materials and methods: Patients treated with prior radiation doses > 65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library. Results: Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review. Conclusions: IMBT could play an important role in the retreatment of recurrent head and neck cancer.

UR - https://www.scopus.com/pages/publications/85037109713

U2 - 10.5301/tj.5000614

DO - 10.5301/tj.5000614

M3 - Scientific review articles

C2 - 28291904

AN - SCOPUS:85037109713

SN - 0300-8916

VL - 103

SP - 516

EP - 524

JO - Tumori

JF - Tumori

IS - 6

ER -

Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review

Abstract

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