Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-κB

Ming Fei Lang*, Armin Schneider, Carola Krüger, Roland Schmid, Roman Dziarski, Markus Schwaninger

*Corresponding author for this work
5 Citations (Scopus)


Cerebral ischemia triggers inflammation and apoptosis, and the transcription factor NF-κB is a key regulator of both events. Here, we report on the induction of the peptidoglycan recognition protein-S (PGRP-S) in a mouse model of cerebral ischemia. Upregulation was reduced if the NF-κB subunit RelA was conditionally deleted in the brain. Regulation of PGRP-S transcription by RelA was confirmed in vitro. Cotransfection of a RelA expression plasmid stimulated the expression of a PGRP-S luciferase fusion gene. Mutation of two NF-κB response elements in the PGRP-S promoter disrupted stimulation by RelA. To investigate the function of PGRP-S in cerebral ischemia, we subjected PGRP-S-/- mice to cerebral ischemia. However, there was no difference in the infarct size in PGRP-S-deficient mice compared to controls. In summary, the data show that PGRP-S is induced in cerebral ischemia by RelA, but its role in ischemia is unclear.

Original languageEnglish
JournalNeuroscience Letters
Issue number2
Pages (from-to)138-141
Number of pages4
Publication statusPublished - 10.01.2008

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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