Pemphigoid gestationis: Treatment with immunoapheresis

Stefan Wöhrl; Alexandra Geusau; Franz Karlhofer; Kurt Derfler; Georg Stingl; Detlef Zillikens

doi:10.1046/j.1610-0387.2003.t01-1-03509.x

Pemphigoid gestationis: Treatment with immunoapheresis

Stefan Wöhrl^*, Alexandra Geusau, Franz Karlhofer, Kurt Derfler, Georg Stingl, Detlef Zillikens

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

University of Vienna

32 Citations (Scopus)

Abstract

Background: Pemphigoid (herpes) gestationis is a rare blistering disease of pregnancy. Topical and systemic corticosteroids and antihistamines are usually sufficient for treatment. Case report: A patient suffering from severe, therapy-resistant pemphigoid gestationis was successfully treated with the additional use of six sessions of immunoapheresis. Systemic corticosteroids could be tapered and serum autoantibody levels to bullous pemphigoid antigen 2 (BPAG2 = BP180) significantly dropped during this treatment. Conclusion: Immunoapheresis represents a helpful therapeutic option with few side effects for severe cases of pemphigoid gestationis, unresponsive to conventional treatment.

Original language	English
Journal	JDDG - Journal of the German Society of Dermatology
Volume	1
Issue number	2
Pages (from-to)	126-130
Number of pages	5
ISSN	1610-0379
DOIs	https://doi.org/10.1046/j.1610-0387.2003.t01-1-03509.x
Publication status	Published - 01.02.2003

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abstract = "Background: Pemphigoid (herpes) gestationis is a rare blistering disease of pregnancy. Topical and systemic corticosteroids and antihistamines are usually sufficient for treatment. Case report: A patient suffering from severe, therapy-resistant pemphigoid gestationis was successfully treated with the additional use of six sessions of immunoapheresis. Systemic corticosteroids could be tapered and serum autoantibody levels to bullous pemphigoid antigen 2 (BPAG2 = BP180) significantly dropped during this treatment. Conclusion: Immunoapheresis represents a helpful therapeutic option with few side effects for severe cases of pemphigoid gestationis, unresponsive to conventional treatment.",

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T1 - Pemphigoid gestationis: Treatment with immunoapheresis

AU - Wöhrl, Stefan

AU - Geusau, Alexandra

AU - Karlhofer, Franz

AU - Derfler, Kurt

AU - Stingl, Georg

AU - Zillikens, Detlef

PY - 2003/2/1

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N2 - Background: Pemphigoid (herpes) gestationis is a rare blistering disease of pregnancy. Topical and systemic corticosteroids and antihistamines are usually sufficient for treatment. Case report: A patient suffering from severe, therapy-resistant pemphigoid gestationis was successfully treated with the additional use of six sessions of immunoapheresis. Systemic corticosteroids could be tapered and serum autoantibody levels to bullous pemphigoid antigen 2 (BPAG2 = BP180) significantly dropped during this treatment. Conclusion: Immunoapheresis represents a helpful therapeutic option with few side effects for severe cases of pemphigoid gestationis, unresponsive to conventional treatment.

AB - Background: Pemphigoid (herpes) gestationis is a rare blistering disease of pregnancy. Topical and systemic corticosteroids and antihistamines are usually sufficient for treatment. Case report: A patient suffering from severe, therapy-resistant pemphigoid gestationis was successfully treated with the additional use of six sessions of immunoapheresis. Systemic corticosteroids could be tapered and serum autoantibody levels to bullous pemphigoid antigen 2 (BPAG2 = BP180) significantly dropped during this treatment. Conclusion: Immunoapheresis represents a helpful therapeutic option with few side effects for severe cases of pemphigoid gestationis, unresponsive to conventional treatment.

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Pemphigoid gestationis: Treatment with immunoapheresis

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