PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus

Renate Willoh; Christine Zühlke; Barbara Gerdes; Stefan Wiese; Ulrike Thies

doi:10.1111/j.1399-0004.1993.tb03828.x

PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus

Renate Willoh, Christine Zühlke^*, Barbara Gerdes, Stefan Wiese, Ulrike Thies

^*Corresponding author for this work

Institute of Human Genetics

1 Citation (Scopus)

Abstract

Willoh R, Zühlke C, Gerdes B, Wiese S, Thies U. PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus. Clin Genet 1993: 43: 321–323. © Munksgaard, 1993 The polymorphic probe BJ56PS18 defined the genetic locus D4S127 closely linked to the Huntington disease (HD) gene. BJ56PS18 detects a three‐allelic polymorphism after PvuII digestion in Southern blots. For rapid genotyping in HD‐families, two different PCR conditions were established.

Original language	English
Journal	Clinical Genetics
Volume	43
Issue number	6
Pages (from-to)	321-323
Number of pages	3
ISSN	0009-9163
DOIs	https://doi.org/10.1111/j.1399-0004.1993.tb03828.x
Publication status	Published - 06.1993

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10.1111/j.1399-0004.1993.tb03828.x

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title = "PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus",

abstract = "Willoh R, Z{\"u}hlke C, Gerdes B, Wiese S, Thies U. PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus. Clin Genet 1993: 43: 321–323. {\textcopyright} Munksgaard, 1993 The polymorphic probe BJ56PS18 defined the genetic locus D4S127 closely linked to the Huntington disease (HD) gene. BJ56PS18 detects a three‐allelic polymorphism after PvuII digestion in Southern blots. For rapid genotyping in HD‐families, two different PCR conditions were established.",

author = "Renate Willoh and Christine Z{\"u}hlke and Barbara Gerdes and Stefan Wiese and Ulrike Thies",

year = "1993",

month = jun,

doi = "10.1111/j.1399-0004.1993.tb03828.x",

language = "English",

volume = "43",

pages = "321--323",

journal = "Clinical Genetics",

issn = "0009-9163",

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T1 - PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus

AU - Willoh, Renate

AU - Zühlke, Christine

AU - Gerdes, Barbara

AU - Wiese, Stefan

AU - Thies, Ulrike

PY - 1993/6

Y1 - 1993/6

N2 - Willoh R, Zühlke C, Gerdes B, Wiese S, Thies U. PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus. Clin Genet 1993: 43: 321–323. © Munksgaard, 1993 The polymorphic probe BJ56PS18 defined the genetic locus D4S127 closely linked to the Huntington disease (HD) gene. BJ56PS18 detects a three‐allelic polymorphism after PvuII digestion in Southern blots. For rapid genotyping in HD‐families, two different PCR conditions were established.

AB - Willoh R, Zühlke C, Gerdes B, Wiese S, Thies U. PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus. Clin Genet 1993: 43: 321–323. © Munksgaard, 1993 The polymorphic probe BJ56PS18 defined the genetic locus D4S127 closely linked to the Huntington disease (HD) gene. BJ56PS18 detects a three‐allelic polymorphism after PvuII digestion in Southern blots. For rapid genotyping in HD‐families, two different PCR conditions were established.

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U2 - 10.1111/j.1399-0004.1993.tb03828.x

DO - 10.1111/j.1399-0004.1993.tb03828.x

M3 - Journal articles

C2 - 8103713

AN - SCOPUS:0027184469

VL - 43

SP - 321

EP - 323

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 6

ER -

PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus

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