PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus

Renate Willoh, Christine Zühlke*, Barbara Gerdes, Stefan Wiese, Ulrike Thies

*Corresponding author for this work
1 Citation (Scopus)

Abstract

Willoh R, Zühlke C, Gerdes B, Wiese S, Thies U. PCR analysis of a three‐allelic PvuII—RFLP at D4S127 closely linked to the Huntington disease locus. Clin Genet 1993: 43: 321–323. © Munksgaard, 1993 The polymorphic probe BJ56PS18 defined the genetic locus D4S127 closely linked to the Huntington disease (HD) gene. BJ56PS18 detects a three‐allelic polymorphism after PvuII digestion in Southern blots. For rapid genotyping in HD‐families, two different PCR conditions were established.

Original languageEnglish
JournalClinical Genetics
Volume43
Issue number6
Pages (from-to)321-323
Number of pages3
ISSN0009-9163
DOIs
Publication statusPublished - 06.1993

Research Areas and Centers

  • Research Area: Medical Genetics

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