TY - JOUR
T1 - Pathogenesis of epidermolysis bullosa acquisita
AU - Ludwig, Ralf J.
AU - Zillikens, Detlef
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies to type VII collagen. Clinically, a noninflammatory and an inflammatory variant of EBA can be distinguished. Despite major achievements in the understanding of EBA, current therapeutic options are far from optimal. However, with an emerging and more detailed understanding of the events ultimately leading to blister formation in EBA, novel therapeutic options may become available for patients with EBA. Therefore, this article reviews the current understanding of the pathogenesis of EBA and may indicate possible avenues towards a more targeted therapy for EBA and possibly other antibody-mediated autoimmune diseases.
AB - Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies to type VII collagen. Clinically, a noninflammatory and an inflammatory variant of EBA can be distinguished. Despite major achievements in the understanding of EBA, current therapeutic options are far from optimal. However, with an emerging and more detailed understanding of the events ultimately leading to blister formation in EBA, novel therapeutic options may become available for patients with EBA. Therefore, this article reviews the current understanding of the pathogenesis of EBA and may indicate possible avenues towards a more targeted therapy for EBA and possibly other antibody-mediated autoimmune diseases.
UR - http://www.scopus.com/inward/record.url?scp=79956283478&partnerID=8YFLogxK
U2 - 10.1016/j.det.2011.03.003
DO - 10.1016/j.det.2011.03.003
M3 - Scientific review articles
C2 - 21605817
AN - SCOPUS:79956283478
SN - 0733-8635
VL - 29
SP - 493
EP - 501
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 3
ER -