Pathogenesis of epidermolysis bullosa acquisita

Ralf J. Ludwig*, Detlef Zillikens

*Corresponding author for this work
    19 Citations (Scopus)

    Abstract

    Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies to type VII collagen. Clinically, a noninflammatory and an inflammatory variant of EBA can be distinguished. Despite major achievements in the understanding of EBA, current therapeutic options are far from optimal. However, with an emerging and more detailed understanding of the events ultimately leading to blister formation in EBA, novel therapeutic options may become available for patients with EBA. Therefore, this article reviews the current understanding of the pathogenesis of EBA and may indicate possible avenues towards a more targeted therapy for EBA and possibly other antibody-mediated autoimmune diseases.

    Original languageEnglish
    JournalDermatologic Clinics
    Volume29
    Issue number3
    Pages (from-to)493-501
    Number of pages9
    ISSN0733-8635
    DOIs
    Publication statusPublished - 01.07.2011

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