Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

J. A. Obeso; M. Stamelou; C. G. Goetz; W. Poewe; A. E. Lang; D. Weintraub; D. Burn; G. M. Halliday; E. Bezard; S. Przedborski; S. Lehericy; D. J. Brooks; J. C. Rothwell; M. Hallett; M. R. DeLong; C. Marras; C. M. Tanner; G. W. Ross; J. W. Langston; C. Klein; V. Bonifati; J. Jankovic; A. M. Lozano; G. Deuschl; H. Bergman; E. Tolosa; M. Rodriguez-Violante; S. Fahn; R. B. Postuma; D. Berg; K. Marek; D. G. Standaert; D. J. Surmeier; C. W. Olanow; J. H. Kordower; P. Calabresi; Anthony Henry Vernon Schapira; A. J. Stoessl

doi:10.1002/mds.27115

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

J. A. Obeso^*, M. Stamelou, C. G. Goetz, W. Poewe, A. E. Lang, D. Weintraub, D. Burn, G. M. Halliday, E. Bezard, S. Przedborski, S. Lehericy, D. J. Brooks, J. C. Rothwell, M. Hallett, M. R. DeLong, C. Marras, C. M. Tanner, G. W. Ross, J. W. Langston, C. KleinV. Bonifati, J. Jankovic, A. M. Lozano, G. Deuschl, H. Bergman, E. Tolosa, M. Rodriguez-Violante, S. Fahn, R. B. Postuma, D. Berg, K. Marek, D. G. Standaert, D. J. Surmeier, C. W. Olanow, J. H. Kordower, P. Calabresi, Anthony Henry Vernon Schapira, A. J. Stoessl

^*Corresponding author for this work

Institute of Neurogenetics

237 Citations (Scopus)

Abstract

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

Original language	English
Journal	Movement Disorders
Volume	32
Issue number	9
Pages (from-to)	1264-1310
Number of pages	47
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.27115
Publication status	Published - 09.2017

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Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D. J., Rothwell, J. C., Hallett, M., DeLong, M. R., Marras, C., Tanner, C. M., Ross, G. W., Langston, J. W., ... Stoessl, A. J. (2017). Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy. Movement Disorders, 32(9), 1264-1310. https://doi.org/10.1002/mds.27115

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title = "Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy",

abstract = "This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.",

author = "Obeso, {J. A.} and M. Stamelou and Goetz, {C. G.} and W. Poewe and Lang, {A. E.} and D. Weintraub and D. Burn and Halliday, {G. M.} and E. Bezard and S. Przedborski and S. Lehericy and Brooks, {D. J.} and Rothwell, {J. C.} and M. Hallett and DeLong, {M. R.} and C. Marras and Tanner, {C. M.} and Ross, {G. W.} and Langston, {J. W.} and C. Klein and V. Bonifati and J. Jankovic and Lozano, {A. M.} and G. Deuschl and H. Bergman and E. Tolosa and M. Rodriguez-Violante and S. Fahn and Postuma, {R. B.} and D. Berg and K. Marek and Standaert, {D. G.} and Surmeier, {D. J.} and Olanow, {C. W.} and Kordower, {J. H.} and P. Calabresi and Schapira, {Anthony Henry Vernon} and Stoessl, {A. J.}",

note = "Publisher Copyright: {\textcopyright} 2017 International Parkinson and Movement Disorder Society",

year = "2017",

month = sep,

doi = "10.1002/mds.27115",

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volume = "32",

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Obeso, JA, Stamelou, M, Goetz, CG, Poewe, W, Lang, AE, Weintraub, D, Burn, D, Halliday, GM, Bezard, E, Przedborski, S, Lehericy, S, Brooks, DJ, Rothwell, JC, Hallett, M, DeLong, MR, Marras, C, Tanner, CM, Ross, GW, Langston, JW, Klein, C, Bonifati, V, Jankovic, J, Lozano, AM, Deuschl, G, Bergman, H, Tolosa, E, Rodriguez-Violante, M, Fahn, S, Postuma, RB, Berg, D, Marek, K, Standaert, DG, Surmeier, DJ, Olanow, CW, Kordower, JH, Calabresi, P, Schapira, AHV & Stoessl, AJ 2017, 'Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy', Movement Disorders, vol. 32, no. 9, pp. 1264-1310. https://doi.org/10.1002/mds.27115

TY - JOUR

T1 - Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

AU - Obeso, J. A.

AU - Stamelou, M.

AU - Goetz, C. G.

AU - Poewe, W.

AU - Lang, A. E.

AU - Weintraub, D.

AU - Burn, D.

AU - Halliday, G. M.

AU - Bezard, E.

AU - Przedborski, S.

AU - Lehericy, S.

AU - Brooks, D. J.

AU - Rothwell, J. C.

AU - Hallett, M.

AU - DeLong, M. R.

AU - Marras, C.

AU - Tanner, C. M.

AU - Ross, G. W.

AU - Langston, J. W.

AU - Klein, C.

AU - Bonifati, V.

AU - Jankovic, J.

AU - Lozano, A. M.

AU - Deuschl, G.

AU - Bergman, H.

AU - Tolosa, E.

AU - Rodriguez-Violante, M.

AU - Fahn, S.

AU - Postuma, R. B.

AU - Berg, D.

AU - Marek, K.

AU - Standaert, D. G.

AU - Surmeier, D. J.

AU - Olanow, C. W.

AU - Kordower, J. H.

AU - Calabresi, P.

AU - Schapira, Anthony Henry Vernon

AU - Stoessl, A. J.

PY - 2017/9

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N2 - This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

AB - This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

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DO - 10.1002/mds.27115

M3 - Scientific review articles

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AN - SCOPUS:85028967067

SN - 0885-3185

VL - 32

SP - 1264

EP - 1310

JO - Movement Disorders

JF - Movement Disorders

IS - 9

ER -

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

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