TY - JOUR
T1 - Parkinson's disease in the Western Pacific Region
AU - Lim, Shen Yang
AU - Tan, Ai Huey
AU - Ahmad-Annuar, Azlina
AU - Klein, Christine
AU - Tan, Louis C.S.
AU - Rosales, Raymond L.
AU - Bhidayasiri, Roongroj
AU - Wu, Yih Ru
AU - Shang, Hui Fang
AU - Evans, Andrew H.
AU - Pal, Pramod K.
AU - Hattori, Nobutaka
AU - Tan, Chong Tin
AU - Jeon, Beomseok
AU - Tan, Eng King
AU - Lang, Anthony E.
PY - 2019/9
Y1 - 2019/9
N2 - 1·8 billion people of diverse ethnicities and cultures live in the Western Pacific Region. The increasing longevity of populations in this region is a major contributor to the exponential increase in Parkinson's disease prevalence worldwide. Differences exist between Parkinson's disease in the Western Pacific Region and in Europe and North America that might provide important insights into our understanding of the disease and approaches to management. For example, some genetic factors (such as LRRK2 mutations or variants) differ, environmental exposures might play differential roles in modulating the risk of Parkinson's disease, and fewer dyskinesias are reported, with some differences in the profile of non-motor symptoms and comorbidities. Gaps in awareness of the disease and inequitable access to treatments pose challenges. Further improvements in infrastructure, clinical governance, and services, and concerted collaborative efforts in training and research, including greater representation of the Western Pacific Region in clinical trials, will improve care of patients with Parkinson's disease in this region and beyond.
AB - 1·8 billion people of diverse ethnicities and cultures live in the Western Pacific Region. The increasing longevity of populations in this region is a major contributor to the exponential increase in Parkinson's disease prevalence worldwide. Differences exist between Parkinson's disease in the Western Pacific Region and in Europe and North America that might provide important insights into our understanding of the disease and approaches to management. For example, some genetic factors (such as LRRK2 mutations or variants) differ, environmental exposures might play differential roles in modulating the risk of Parkinson's disease, and fewer dyskinesias are reported, with some differences in the profile of non-motor symptoms and comorbidities. Gaps in awareness of the disease and inequitable access to treatments pose challenges. Further improvements in infrastructure, clinical governance, and services, and concerted collaborative efforts in training and research, including greater representation of the Western Pacific Region in clinical trials, will improve care of patients with Parkinson's disease in this region and beyond.
UR - http://www.scopus.com/inward/record.url?scp=85071345703&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(19)30195-4
DO - 10.1016/S1474-4422(19)30195-4
M3 - Scientific review articles
C2 - 31175000
AN - SCOPUS:85071345703
SN - 1474-4422
VL - 18
SP - 865
EP - 879
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 9
ER -