Abstract

The discovery of the Parkin gene in 1998 cemented the concept that mutations in a single gene can cause Parkinson’s disease (PD). Parkin mutations are the most common known cause of early-onset PD, accounting for up to 77% of the cases with an age of onset <30 years [1]. In this chapter, we will give an overview of the clinical and pathological features of Parkin-associated PD, followed by a detailed description of the Parkin gene and protein. We will cover known functions of Parkin and disease models and finally consider issues of genetic testing and new therapeutic perspectives.

Original languageEnglish
Title of host publicationParkinson's Disease, Second Edition
Number of pages14
PublisherCRC Press
Publication date01.01.2012
Pages161-174
ISBN (Print)9781439807149
ISBN (Electronic)9781439807156
DOIs
Publication statusPublished - 01.01.2012

Fingerprint

Dive into the research topics of 'Parkin-associated Parkinson’s disease'. Together they form a unique fingerprint.

Cite this