Pannexins in ischemia-induced neurodegeneration

Panagiotis Bargiotas, Antje Krenz, Sheriar G. Hormuzdi, Dirk A. Ridder, Anne Herb, Waleed Barakat, Silvia Penuela, Jakob Von Engelhardt, Hannah Monyer*, Markus Schwaninger

*Corresponding author for this work
131 Citations (Scopus)


Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form largepore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed experiments in Px1 -/-, Px2 -/-, and Px1 -/-Px2 -/- knockout mice. IL-1β release, channel function in astrocytes, and cortical spreading depolarization were not altered in Px1 -/-Px2 -/- mice, indicating that, in contrast to previous concepts, these processes occur normally in the absence of pannexin channels. However, ischemia-induced dye release from cortical neurons was lower, indicating that channel function in Px1 -/-Px2 -/- neurons was impaired. Furthermore, Px1 -/-Px2 -/-mice had a better functional outcome and smaller infarcts than wild-type mice when subjected to ischemic stroke. In conclusion, our data demonstrate that Px1 and Px2 underlie channel function in neurons and contribute to ischemic brain damage.

Original languageEnglish
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number51
Pages (from-to)20772-20777
Number of pages6
Publication statusPublished - 20.12.2011

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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