Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial

Joerg Mueller; Inger M. Skogseid; Reiner Benecke; Andreas Kupsch; Thomas Trottenberg; Werner Poewe; Gerd H. Schneider; Wilhelm Eisner; Alexander Wolters; J. U. Müller; Günther Deuschl; Marcus O. Pinsker; Geir K. Roeste; Juliane Vollmer-Haase; Angela Brentrup; Martin Krause; Volker Tronnier; Alfons Schnitzler; Jüergen Voges; Guido Nikkhah; Jan Vesper; Markus Naumann; Jens Volkmann

doi:10.1002/mds.21783

Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial

Joerg Mueller, Inger M. Skogseid, Reiner Benecke, Andreas Kupsch, Thomas Trottenberg, Werner Poewe, Gerd H. Schneider, Wilhelm Eisner, Alexander Wolters, J. U. Müller, Günther Deuschl, Marcus O. Pinsker, Geir K. Roeste, Juliane Vollmer-Haase, Angela Brentrup, Martin Krause, Volker Tronnier, Alfons Schnitzler, Jüergen Voges, Guido NikkhahJan Vesper, Markus Naumann, Jens Volkmann^*

^*Corresponding author for this work

University of Kiel

114 Citations (Scopus)

Abstract

As part of the first randomized, sham-timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.

Original language	English
Journal	Movement Disorders
Volume	23
Issue number	1
Pages (from-to)	131-134
Number of pages	4
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.21783
Publication status	Published - 15.01.2008

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Mueller, J., Skogseid, I. M., Benecke, R., Kupsch, A., Trottenberg, T., Poewe, W., Schneider, G. H., Eisner, W., Wolters, A., Müller, J. U., Deuschl, G., Pinsker, M. O., Roeste, G. K., Vollmer-Haase, J., Brentrup, A., Krause, M., Tronnier, V., Schnitzler, A., Voges, J., ... Volkmann, J. (2008). Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial. Movement Disorders, 23(1), 131-134. https://doi.org/10.1002/mds.21783

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title = "Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial",

abstract = "As part of the first randomized, sham-timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.",

author = "Joerg Mueller and Skogseid, {Inger M.} and Reiner Benecke and Andreas Kupsch and Thomas Trottenberg and Werner Poewe and Schneider, {Gerd H.} and Wilhelm Eisner and Alexander Wolters and M{\"u}ller, {J. U.} and G{\"u}nther Deuschl and Pinsker, {Marcus O.} and Roeste, {Geir K.} and Juliane Vollmer-Haase and Angela Brentrup and Martin Krause and Volker Tronnier and Alfons Schnitzler and J{\"u}ergen Voges and Guido Nikkhah and Jan Vesper and Markus Naumann and Jens Volkmann",

year = "2008",

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day = "15",

doi = "10.1002/mds.21783",

language = "English",

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journal = "Movement Disorders",

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Mueller, J, Skogseid, IM, Benecke, R, Kupsch, A, Trottenberg, T, Poewe, W, Schneider, GH, Eisner, W, Wolters, A, Müller, JU, Deuschl, G, Pinsker, MO, Roeste, GK, Vollmer-Haase, J, Brentrup, A, Krause, M, Tronnier, V, Schnitzler, A, Voges, J, Nikkhah, G, Vesper, J, Naumann, M & Volkmann, J 2008, 'Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial', Movement Disorders, vol. 23, no. 1, pp. 131-134. https://doi.org/10.1002/mds.21783

TY - JOUR

T1 - Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia

T2 - Results from a prospective, randomized sham-controlled trial

AU - Mueller, Joerg

AU - Skogseid, Inger M.

AU - Benecke, Reiner

AU - Kupsch, Andreas

AU - Trottenberg, Thomas

AU - Poewe, Werner

AU - Schneider, Gerd H.

AU - Eisner, Wilhelm

AU - Wolters, Alexander

AU - Müller, J. U.

AU - Deuschl, Günther

AU - Pinsker, Marcus O.

AU - Roeste, Geir K.

AU - Vollmer-Haase, Juliane

AU - Brentrup, Angela

AU - Krause, Martin

AU - Tronnier, Volker

AU - Schnitzler, Alfons

AU - Voges, Jüergen

AU - Nikkhah, Guido

AU - Vesper, Jan

AU - Naumann, Markus

AU - Volkmann, Jens

PY - 2008/1/15

Y1 - 2008/1/15

N2 - As part of the first randomized, sham-timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.

AB - As part of the first randomized, sham-timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.

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SN - 0885-3185

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SP - 131

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JO - Movement Disorders

JF - Movement Disorders

IS - 1

ER -

Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial

Abstract

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