p63 expression profile in normal and malignant prostate epithelial cells

Leland D. Davis, Wei Zhang, Axel Merseburger, Denise Young, Linda Xu, Johng S. Rhim, Judd W. Moul, Shiv Srivastava*, Isabell A. Sesterhenn

*Corresponding author for this work
29 Citations (Scopus)


p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.

Original languageEnglish
JournalAnticancer Research
Issue number6 C
Pages (from-to)3819-3825
Number of pages7
Publication statusPublished - 11.2002

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


Dive into the research topics of 'p63 expression profile in normal and malignant prostate epithelial cells'. Together they form a unique fingerprint.

Cite this