Abstract
p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.
Original language | English |
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Journal | Anticancer Research |
Volume | 22 |
Issue number | 6 C |
Pages (from-to) | 3819-3825 |
Number of pages | 7 |
ISSN | 0250-7005 |
Publication status | Published - 11.2002 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)