TY - JOUR
T1 - p53 mutations in carcinoma of the esophagus and gastroesophageal junction
AU - Sengpiel, C.
AU - Konig, I. R.
AU - Rades, D.
AU - Noack, F.
AU - Duchrow, M.
AU - Schild, S. E.
AU - Ludwig, D.
AU - Homann, N.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/1
Y1 - 2009/1
N2 - Background: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. Methods: p53 mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. Results and Conclusions: p53 mutations were found in 26 of 68 SSC (38.2%) and in 12 of 35 AC (34.5%). We only found G > T transversions in smokers with SCC. The survival of patients was not affected by p53 mutational status. In our study, the frequency and mutational spectrum of mutant p53 is similar in both histological types without prognostic relevance.
AB - Background: Recent studies suggested p53 mutations as a prognostic factor. Tumors of the esophagus and gastroesophageal (GE) junction show raising incidence with a general poor prognosis. Methods: p53 mutational spectra in 103 patients (68 squamous cell carcinoma/SCC and 35 adenocarcinoma/AC) were compared to clinical and pathologic data. Results and Conclusions: p53 mutations were found in 26 of 68 SSC (38.2%) and in 12 of 35 AC (34.5%). We only found G > T transversions in smokers with SCC. The survival of patients was not affected by p53 mutational status. In our study, the frequency and mutational spectrum of mutant p53 is similar in both histological types without prognostic relevance.
UR - http://www.scopus.com/inward/record.url?scp=60549112412&partnerID=8YFLogxK
U2 - 10.1080/07357900802161047
DO - 10.1080/07357900802161047
M3 - Scientific review articles
C2 - 19160092
AN - SCOPUS:60549112412
SN - 0735-7907
VL - 27
SP - 96
EP - 104
JO - Cancer Investigation
JF - Cancer Investigation
IS - 1
ER -
