P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh; Rachel Sarig; Elad Bar Natan; Alina Molchadsky; Shalom Madar; Chamutal Bornstein; Yosef Buganim; Tirosh Shapira; Naomi Goldfinger; Ralf Paus; Varda Rotter

doi:10.1016/j.febslet.2010.04.058

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh^*, Rachel Sarig, Elad Bar Natan, Alina Molchadsky, Shalom Madar, Chamutal Bornstein, Yosef Buganim, Tirosh Shapira, Naomi Goldfinger, Ralf Paus, Varda Rotter

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

The Weizmann Institute of Science

16 Citations (Scopus)

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

Original language	English
Journal	FEBS Letters
Volume	584
Issue number	11
Pages (from-to)	2473-2477
Number of pages	5
ISSN	0014-5793
DOIs	https://doi.org/10.1016/j.febslet.2010.04.058
Publication status	Published - 01.06.2010

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title = "P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss",

abstract = "The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.",

author = "Ran Brosh and Rachel Sarig and Natan, {Elad Bar} and Alina Molchadsky and Shalom Madar and Chamutal Bornstein and Yosef Buganim and Tirosh Shapira and Naomi Goldfinger and Ralf Paus and Varda Rotter",

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T1 - P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

AU - Brosh, Ran

AU - Sarig, Rachel

AU - Natan, Elad Bar

AU - Molchadsky, Alina

AU - Madar, Shalom

AU - Bornstein, Chamutal

AU - Buganim, Yosef

AU - Shapira, Tirosh

AU - Goldfinger, Naomi

AU - Paus, Ralf

AU - Rotter, Varda

PY - 2010/6/1

Y1 - 2010/6/1

N2 - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

AB - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

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JO - FEBS Letters

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ER -

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Abstract

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