Ovarielle Stimulation: Ein erhöhtes Karzinomrisiko?

In daily practice there are frequently indications of a possibly higher risk of gynecologic malignoma following pregnancy treatment with hormonal stimulation. The data indicate a tendency to higher risk of such disease. It is known that a sterility anamnesis correlates to higher risk of endometrial and ovarian cancer. Other factors for endometrial cancer include infertility and long-term clomifen stimulation. For patients wishing pregnancy the incidence of borderline ovarian tumors appears slightly higher following hormonal stimulation. Current studies indicate that this does not apply to ovarian cancer. Data concerning breast cancer are strongly heterogeneous and show increased risk in some subgroup analyses, but at the present this appears to be unproven. Longer observation periods are needed, especially after ovarian stimulation, because the carcinomic disease peak of the study participants will be reached some years from now. More retrospective epidemiologic analyses of the available data should be carried out in national in-vitro-fertilization registers to substantiate present knowledge.