Orexin (hypocretin) gene expression in rat ependymal cells

M. Kummer; S. J. Neidert; O. Jöhren; P. Dominiak

doi:10.1097/00001756-200107200-00015

Orexin (hypocretin) gene expression in rat ependymal cells

M. Kummer, S. J. Neidert, O. Jöhren^*, P. Dominiak

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

University of Kiel

11 Citations (Scopus)

Abstract

The expression of prepro-orexin (PPO) mRNA in the rat brain was investigated by in situ hybridization histochemistry. In the lateral and posterior hypothalamic areas, which are considered to produce exclusively PPO mRNA, we found high levels of PPO mRNA expressions. We also localized PPO mRNA hybridization signals at lower levels around the lateral ventricles, the third and fourth ventricle. Cellular analysis by emulsion autoradiography revealed the expression of PPO mRNA in the ependymal cell layer. Our results demonstrate that beside the lateral and posterior hypothalamus PPO mRNA is expressed in ependymal cells.

Original language	English
Journal	NeuroReport
Volume	12
Issue number	10
Pages (from-to)	2117-2120
Number of pages	4
ISSN	0959-4965
DOIs	https://doi.org/10.1097/00001756-200107200-00015
Publication status	Published - 20.07.2001

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1097/00001756-200107200-00015

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title = "Orexin (hypocretin) gene expression in rat ependymal cells",

abstract = "The expression of prepro-orexin (PPO) mRNA in the rat brain was investigated by in situ hybridization histochemistry. In the lateral and posterior hypothalamic areas, which are considered to produce exclusively PPO mRNA, we found high levels of PPO mRNA expressions. We also localized PPO mRNA hybridization signals at lower levels around the lateral ventricles, the third and fourth ventricle. Cellular analysis by emulsion autoradiography revealed the expression of PPO mRNA in the ependymal cell layer. Our results demonstrate that beside the lateral and posterior hypothalamus PPO mRNA is expressed in ependymal cells.",

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AU - Kummer, M.

AU - Neidert, S. J.

AU - Jöhren, O.

AU - Dominiak, P.

PY - 2001/7/20

Y1 - 2001/7/20

N2 - The expression of prepro-orexin (PPO) mRNA in the rat brain was investigated by in situ hybridization histochemistry. In the lateral and posterior hypothalamic areas, which are considered to produce exclusively PPO mRNA, we found high levels of PPO mRNA expressions. We also localized PPO mRNA hybridization signals at lower levels around the lateral ventricles, the third and fourth ventricle. Cellular analysis by emulsion autoradiography revealed the expression of PPO mRNA in the ependymal cell layer. Our results demonstrate that beside the lateral and posterior hypothalamus PPO mRNA is expressed in ependymal cells.

AB - The expression of prepro-orexin (PPO) mRNA in the rat brain was investigated by in situ hybridization histochemistry. In the lateral and posterior hypothalamic areas, which are considered to produce exclusively PPO mRNA, we found high levels of PPO mRNA expressions. We also localized PPO mRNA hybridization signals at lower levels around the lateral ventricles, the third and fourth ventricle. Cellular analysis by emulsion autoradiography revealed the expression of PPO mRNA in the ependymal cell layer. Our results demonstrate that beside the lateral and posterior hypothalamus PPO mRNA is expressed in ependymal cells.

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DO - 10.1097/00001756-200107200-00015

M3 - Journal articles

C2 - 11447318

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SN - 0959-4965

VL - 12

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EP - 2120

JO - NeuroReport

JF - NeuroReport

IS - 10

ER -

Orexin (hypocretin) gene expression in rat ependymal cells

Abstract

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