Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: An updated meta-analysis

Georg Griesinger; Efstratios Michaelis Kolibianakis; Christos Venetis; Klaus Diedrich; Basil Tarlatzis

doi:10.1016/j.fertnstert.2010.04.025

Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: An updated meta-analysis

Georg Griesinger^*, Efstratios Michaelis Kolibianakis, Christos Venetis, Klaus Diedrich, Basil Tarlatzis

^*Corresponding author for this work

Clinic of Gynecology and Obstetrics

63 Citations (Scopus)

Abstract

Ongoing pregnancy rate (PR) per randomized woman was found to be significantly lower in patients with oral contraceptive (OC) pill pretreatment (relative risk: 0.80, 95% confidence interval [CI]: 0.66-0.97; rate difference: -5%, 95% CI: -10% to -1%; fixed effects model) after pooling data from six randomized controlled trials encompassing 1,343 patients. Duration of stimulation (weighted mean difference [WMD]: +1.33 days, 95% CI: +0.61-2.05) and gonadotropin consumption (WMD: +360 IUs, 95% CI: +158-563) were significantly increased after OC pretreatment, but there was no statistically significant gain in the number of cumulus-oocyte complexes (WMD: +0.6 cumulus-oocyte complexes, 95% CI: -0.08-1.25).

Original language	English
Journal	Fertility and Sterility
Volume	94
Issue number	6
Pages (from-to)	2382-2384
Number of pages	3
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2010.04.025
Publication status	Published - 01.11.2010

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@article{855102f7328d43a4be938d98fb031580,

title = "Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: An updated meta-analysis",

abstract = "Ongoing pregnancy rate (PR) per randomized woman was found to be significantly lower in patients with oral contraceptive (OC) pill pretreatment (relative risk: 0.80, 95% confidence interval [CI]: 0.66-0.97; rate difference: -5%, 95% CI: -10% to -1%; fixed effects model) after pooling data from six randomized controlled trials encompassing 1,343 patients. Duration of stimulation (weighted mean difference [WMD]: +1.33 days, 95% CI: +0.61-2.05) and gonadotropin consumption (WMD: +360 IUs, 95% CI: +158-563) were significantly increased after OC pretreatment, but there was no statistically significant gain in the number of cumulus-oocyte complexes (WMD: +0.6 cumulus-oocyte complexes, 95% CI: -0.08-1.25).",

author = "Georg Griesinger and Kolibianakis, {Efstratios Michaelis} and Christos Venetis and Klaus Diedrich and Basil Tarlatzis",

year = "2010",

month = nov,

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doi = "10.1016/j.fertnstert.2010.04.025",

language = "English",

volume = "94",

pages = "2382--2384",

journal = "Fertility and Sterility",

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Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: An updated meta-analysis. / Griesinger, Georg; Kolibianakis, Efstratios Michaelis; Venetis, Christos et al.
In: Fertility and Sterility, Vol. 94, No. 6, 01.11.2010, p. 2382-2384.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: An updated meta-analysis

AU - Griesinger, Georg

AU - Kolibianakis, Efstratios Michaelis

AU - Venetis, Christos

AU - Diedrich, Klaus

AU - Tarlatzis, Basil

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Ongoing pregnancy rate (PR) per randomized woman was found to be significantly lower in patients with oral contraceptive (OC) pill pretreatment (relative risk: 0.80, 95% confidence interval [CI]: 0.66-0.97; rate difference: -5%, 95% CI: -10% to -1%; fixed effects model) after pooling data from six randomized controlled trials encompassing 1,343 patients. Duration of stimulation (weighted mean difference [WMD]: +1.33 days, 95% CI: +0.61-2.05) and gonadotropin consumption (WMD: +360 IUs, 95% CI: +158-563) were significantly increased after OC pretreatment, but there was no statistically significant gain in the number of cumulus-oocyte complexes (WMD: +0.6 cumulus-oocyte complexes, 95% CI: -0.08-1.25).

AB - Ongoing pregnancy rate (PR) per randomized woman was found to be significantly lower in patients with oral contraceptive (OC) pill pretreatment (relative risk: 0.80, 95% confidence interval [CI]: 0.66-0.97; rate difference: -5%, 95% CI: -10% to -1%; fixed effects model) after pooling data from six randomized controlled trials encompassing 1,343 patients. Duration of stimulation (weighted mean difference [WMD]: +1.33 days, 95% CI: +0.61-2.05) and gonadotropin consumption (WMD: +360 IUs, 95% CI: +158-563) were significantly increased after OC pretreatment, but there was no statistically significant gain in the number of cumulus-oocyte complexes (WMD: +0.6 cumulus-oocyte complexes, 95% CI: -0.08-1.25).

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U2 - 10.1016/j.fertnstert.2010.04.025

DO - 10.1016/j.fertnstert.2010.04.025

M3 - Journal articles

C2 - 20537631

AN - SCOPUS:78049301586

SN - 0015-0282

VL - 94

SP - 2382

EP - 2384

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 6

ER -

Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: An updated meta-analysis

Abstract

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