Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma

Oliver Driemel, Urs D.A. Müller-Richter, Samer G. Hakim, Richard Bauer, Alexander Berndt, Johannes Kleinheinz, Torsten E. Reichert, Hartwig Kosmehl

25 Citations (Scopus)


Background. acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction. Methods. Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, γ2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, β-catenin, E-cadherin, α-smooth-muscle-actin and Fli-1 were done. Results. Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and β-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities. Conclusion. Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.

Original languageEnglish
Article number17
JournalHead and Face Medicine
Issue number1
Publication statusPublished - 22.08.2008


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