TY - JOUR
T1 - Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma
AU - Driemel, Oliver
AU - Müller-Richter, Urs D.A.
AU - Hakim, Samer G.
AU - Bauer, Richard
AU - Berndt, Alexander
AU - Kleinheinz, Johannes
AU - Reichert, Torsten E.
AU - Kosmehl, Hartwig
PY - 2008/8/22
Y1 - 2008/8/22
N2 - Background. acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction. Methods. Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, γ2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, β-catenin, E-cadherin, α-smooth-muscle-actin and Fli-1 were done. Results. Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and β-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities. Conclusion. Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.
AB - Background. acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction. Methods. Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, γ2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, β-catenin, E-cadherin, α-smooth-muscle-actin and Fli-1 were done. Results. Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and β-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities. Conclusion. Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.
UR - http://www.scopus.com/inward/record.url?scp=49649124712&partnerID=8YFLogxK
U2 - 10.1186/1746-160X-4-17
DO - 10.1186/1746-160X-4-17
M3 - Journal articles
C2 - 18671846
AN - SCOPUS:49649124712
SN - 1746-160X
VL - 4
JO - Head and Face Medicine
JF - Head and Face Medicine
IS - 1
M1 - 17
ER -