Optische Koharenztomographie der Kornea und des vorderen Augenabschnitts

Translated title of the contribution: Optical coherence tomography of cornea and anterior segment of the eye

Norbert Koop*, Ralf Brinkmann, Eva Lankenau, Stefan Flache, Ralf Engelhardt, Reginald Birngruber

*Corresponding author for this work
40 Citations (Scopus)


Target: The method of optical coherence tomography (OCT) was investigated regarding its suitability and limits for measuring the cornea and the anterior segment of the eye. Furthermore, the stromal expansion of thermally induced lesions in the cornea directly after irradiation was determined within the scope of the laser thermokeratoplasty (LTK). Material and methods: With the experimental scanning OCT system, x-z sections of the anterior eye segment were made with an optical resolution of about 20 μm axially and 25 μm laterally. Freshly enucleated, tonicized porcine eyes were used as model eyes. Thermal lesions were applied with a continuously emitting laser diode (λ m= 1.86 μm) and various radiation parameters. Before and after coagulation, the cornea was viewed from limbus to limbus in a central OCT scan and the individual coagulation source was measured. Results: Global and local changes of the thickness of the cornea as well as the distance between cornea and lens were measured with high precision. Thermal lesions in their expansion can be clearly presented and matching well with the histologically stained sections, but are not as exactly defined at the edges due to the limited optical resolution, as known from histological preparations. Conclusion: With the OCT method quantitative measuring of the anterior eye segment can be performed in vitro and with reduced resolutions also in vivo. Due to the qualitatively good correspondence regarding the dimensions of thermal damage of the cornea with histologically obtained morphometric results, this method can be used for supervision of coagulation directly after LTK as well as for examination of the individual healing process.

Translated title of the contributionOptical coherence tomography of cornea and anterior segment of the eye
Original languageGerman
Issue number7
Pages (from-to)481-486
Number of pages6
Publication statusPublished - 07.1997

Research Areas and Centers

  • Academic Focus: Biomedical Engineering


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