Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri; Alessa Hutfilz; Lorenz Grimm; Patrik Arnold; Andreas Ebneter; Ralf Brinkmann; Dirk Theisen-Kunde; Boris Považay; Christoph Meier

doi:10.1117/12.2526720

Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Andreas Ebneter, Ralf Brinkmann, Dirk Theisen-Kunde, Boris Považay, Christoph Meier

Bern University of Applied Sciences

Abstract

Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 - 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This "Spectralis Centaurus" system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

Original language	English
Title of host publication	Medical Laser Applications and Laser-Tissue Interactions IX
Editors	Lothar D. Lilge, Carsten M. Philipp
Number of pages	6
Volume	11079
Publisher	SPIE
Publication date	22.07.2019
Article number	1107903
ISBN (Print)	978-151062851-9
DOIs	https://doi.org/10.1117/12.2526720
Publication status	Published - 22.07.2019
Event	Medical Laser Applications and Laser-Tissue Interactions IX 2019 - Munich, Germany Duration: 23.06.2019 → 24.06.2019

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Burri, C., Hutfilz, A., Grimm, L., Arnold, P., Ebneter, A., Brinkmann, R., Theisen-Kunde, D., Považay, B., & Meier, C. (2019). Optical coherence tomography controlled selective retina therapy with a novel microsecond laser. In L. D. Lilge, & C. M. Philipp (Eds.), Medical Laser Applications and Laser-Tissue Interactions IX (Vol. 11079). Article 1107903 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11079). SPIE. https://doi.org/10.1117/12.2526720

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abstract = "Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 - 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This {"}Spectralis Centaurus{"} system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.",

author = "Christian Burri and Alessa Hutfilz and Lorenz Grimm and Patrik Arnold and Andreas Ebneter and Ralf Brinkmann and Dirk Theisen-Kunde and Boris Pova{\v z}ay and Christoph Meier",

note = "Funding Information: Founding: Swiss National Science Foundation, Innovation Agency KTI 25030.1 PFLS-LS Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.; Medical Laser Applications and Laser-Tissue Interactions IX 2019 <br/> ; Conference date: 23-06-2019 Through 24-06-2019",

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Burri, C, Hutfilz, A, Grimm, L, Arnold, P, Ebneter, A, Brinkmann, R , Theisen-Kunde, D, Považay, B & Meier, C 2019, Optical coherence tomography controlled selective retina therapy with a novel microsecond laser. in L D. Lilge & C M. Philipp (eds), Medical Laser Applications and Laser-Tissue Interactions IX. vol. 11079, 1107903, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11079, SPIE, Medical Laser Applications and Laser-Tissue Interactions IX 2019
, Munich, Bavaria, Germany, 23.06.19. https://doi.org/10.1117/12.2526720

Optical coherence tomography controlled selective retina therapy with a novel microsecond laser. / Burri, Christian; Hutfilz, Alessa; Grimm, Lorenz et al.
Medical Laser Applications and Laser-Tissue Interactions IX. ed. / Lothar D. Lilge; Carsten M. Philipp. Vol. 11079 SPIE, 2019. 1107903 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11079).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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T1 - Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

AU - Burri, Christian

AU - Hutfilz, Alessa

AU - Grimm, Lorenz

AU - Arnold, Patrik

AU - Ebneter, Andreas

AU - Brinkmann, Ralf

AU - Theisen-Kunde, Dirk

AU - Považay, Boris

AU - Meier, Christoph

N1 - Funding Information: Founding: Swiss National Science Foundation, Innovation Agency KTI 25030.1 PFLS-LS Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/7/22

Y1 - 2019/7/22

N2 - Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 - 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This "Spectralis Centaurus" system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

AB - Selective retina therapy (SRT) is a short pulse (μs-regime) alternative to conventional laser photocoagulation (LPC) for treatment of retinal diseases. LPC leads to collateral damage of retinal layers adjacent to the retinal pigment epithelium (RPE), including healthy, non-regenerative photoreceptors due to the high thermal load, whereas in SRT, RPE cells are destroyed by microbubbles without damaging the neuronal retina. A novel experimental SRT laser operating at 532 nm wavelength can deliver 2 - 20 μs pulse sequences. Its tight integration into an upgraded diagnostic SPECTRALIS system combines beam control for treatment planning with real-time optical coherence tomography (OCT) overexposure protection of the photoreceptors. This "Spectralis Centaurus" system, was built and preliminary tested on porcine ex-vivo samples, reaching an unprecedented accuracy with unique planning and follow-up capabilities for upcoming clinical cellular level micro-surgery. The combination of OCT with SRT selectively limits cell death to the RPE by precisely controlling energy deposition while optically monitoring tissue response.

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DO - 10.1117/12.2526720

M3 - Conference contribution

SN - 978-151062851-9

VL - 11079

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Laser Applications and Laser-Tissue Interactions IX

A2 - D. Lilge, Lothar

A2 - M. Philipp, Carsten

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T2 - Medical Laser Applications and Laser-Tissue Interactions IX 2019 <br/>

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Burri C, Hutfilz A, Grimm L, Arnold P, Ebneter A, Brinkmann R et al. Optical coherence tomography controlled selective retina therapy with a novel microsecond laser. In D. Lilge L, M. Philipp C, editors, Medical Laser Applications and Laser-Tissue Interactions IX. Vol. 11079. SPIE. 2019. 1107903. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2526720

Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

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