TY - JOUR
T1 - Op-amp based low noise amplifier for magnetic particle spectroscopy
AU - Malhotra, Ankit
AU - Buzug, Thorsten
N1 - Publisher Copyright:
© 2017 Ankit Malhotra et al. published by De Gruyter.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - Magnetic particle spectrometry (MPS) is a novel technique used to measure the magnetization response of superparamagnetic iron oxide nanoparticles (SPIONs). Therefore, it is one of the most important tools for the characterization of the SPIONs for imaging modalities such as magnetic particle imaging (MPI) and Magnetic Resonance Imaging (MRI). In MPS, change in the particle magnetization induces a voltage in a dedicated receive coil. The amplitude of the signal can be very low (ranging from a few nV to 100 µV) depending upon the concentration of the nanoparticles. Hence, the received signal needs to be amplified with a low noise amplifier (LNA). LNA’s paramount task is to amplify the received signal while keeping the noise induced by its own circuitry minimum. In the current research, we purpose modeling, design, and development of a prototyped LNA for MPS. The designed prototype LNA is based on the parallelization technique of Op-amps. The prototyped LNA consists of 16 Op-amps in parallel and is manufactured on a printed circuit board (PCB), with a size of 110.38 mm x 59.46 mm and 234 components. The input noise of the amplifier is approx. 546 pV/Hz with a noise figure (NF) of approx. 1.4 dB with a receive coil termination. Furthermore, a comparison between the prototyped LNA and a commercially available amplifier is shown.
AB - Magnetic particle spectrometry (MPS) is a novel technique used to measure the magnetization response of superparamagnetic iron oxide nanoparticles (SPIONs). Therefore, it is one of the most important tools for the characterization of the SPIONs for imaging modalities such as magnetic particle imaging (MPI) and Magnetic Resonance Imaging (MRI). In MPS, change in the particle magnetization induces a voltage in a dedicated receive coil. The amplitude of the signal can be very low (ranging from a few nV to 100 µV) depending upon the concentration of the nanoparticles. Hence, the received signal needs to be amplified with a low noise amplifier (LNA). LNA’s paramount task is to amplify the received signal while keeping the noise induced by its own circuitry minimum. In the current research, we purpose modeling, design, and development of a prototyped LNA for MPS. The designed prototype LNA is based on the parallelization technique of Op-amps. The prototyped LNA consists of 16 Op-amps in parallel and is manufactured on a printed circuit board (PCB), with a size of 110.38 mm x 59.46 mm and 234 components. The input noise of the amplifier is approx. 546 pV/Hz with a noise figure (NF) of approx. 1.4 dB with a receive coil termination. Furthermore, a comparison between the prototyped LNA and a commercially available amplifier is shown.
UR - http://www.scopus.com/inward/record.url?scp=85059823542&partnerID=8YFLogxK
U2 - 10.1515/cdbme-2017-0125
DO - 10.1515/cdbme-2017-0125
M3 - Journal articles
AN - SCOPUS:85059823542
SN - 2364-5504
VL - 3
SP - 599
EP - 602
JO - Current Directions in Biomedical Engineering
JF - Current Directions in Biomedical Engineering
IS - 2
ER -