Oligomeric nucleic acids as antivirals

Alessandra Mescalchin, Tobias Restle*

*Corresponding author for this work
24 Citations (Scopus)


Based on the natural functions and chemical characteristics of nucleic acids, a variety of novel synthetic drugs and tools to explore biological systems have become available in recent years. To date, a great number of antisense oligonucleotides, RNA interference-based tools, CpG-containing oligonucleotides, catalytic oligonucleotides, decoys and aptamers has been produced synthetically and applied successfully for understanding and manipulating biological processes and in clinical trials to treat a variety of diseases. Their versatility and potency make them equally suited candidates for fighting viral infections. Here, we describe the different types of nucleic acid-based antivirals, their mechanism of action, their advantages and limitations, and their future prospects.

Original languageEnglish
Issue number2
Pages (from-to)1271-1296
Number of pages26
Publication statusPublished - 01.02.2011


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