TY - JOUR
T1 - Occupational exposure characterization in professional sprayers: Clinical utility of oxidative stress biomarkers
AU - Astiz, Mariana
AU - Arnal, Nathalie
AU - de Alaniz, María J.T.
AU - Marra, Carlos Alberto
N1 - Funding Information:
This study was supported by a grant from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) , PIP 112-200801-00697 . We would like to thank Miss Norma Cristalli and Eva Illara de Bozzolo for their excellent technical assistance.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2011/9
Y1 - 2011/9
N2 - The impact of involuntary exposure to pesticides was studied in a group of professional sprayers (S) (25 ± 5 years old) exposed to various agrochemicals for about 10 years. The results were compared with a group of non exposed people (C). S group showed hematological, renal, pancreatic and hepatic biomarkers within the reference values established for the general population, including cholinesterase activity. In spite of that, all the biochemical tests were statistically different compared to C. On the other hand, oxidative stress biomarkers (OSB) such as plasma tocopherol and the total reducing ability of plasma were significantly decreased, while protein carbonyls, thiobarbituric acid-reactive substances, total glutathione and the sum of nitrites and nitrates were increased in the exposed group. Results demonstrated that screening laboratory tests could not be fully sensitive in detecting sub-clinical exposure to pesticides, and also suggest that OSB could be validated and included in health surveillance protocols.
AB - The impact of involuntary exposure to pesticides was studied in a group of professional sprayers (S) (25 ± 5 years old) exposed to various agrochemicals for about 10 years. The results were compared with a group of non exposed people (C). S group showed hematological, renal, pancreatic and hepatic biomarkers within the reference values established for the general population, including cholinesterase activity. In spite of that, all the biochemical tests were statistically different compared to C. On the other hand, oxidative stress biomarkers (OSB) such as plasma tocopherol and the total reducing ability of plasma were significantly decreased, while protein carbonyls, thiobarbituric acid-reactive substances, total glutathione and the sum of nitrites and nitrates were increased in the exposed group. Results demonstrated that screening laboratory tests could not be fully sensitive in detecting sub-clinical exposure to pesticides, and also suggest that OSB could be validated and included in health surveillance protocols.
UR - http://www.scopus.com/inward/record.url?scp=80051577637&partnerID=8YFLogxK
U2 - 10.1016/j.etap.2011.05.010
DO - 10.1016/j.etap.2011.05.010
M3 - Journal articles
C2 - 21843806
AN - SCOPUS:80051577637
SN - 1382-6689
VL - 32
SP - 249
EP - 258
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
IS - 2
ER -
