Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Marcos F. Fondevila; Maria Mercado-Gómez; Amaia Rodríguez; Maria J. Gonzalez-Rellan; Paula Iruzubieta; Víctor Valentí; Javier Escalada; Markus Schwaninger; Vincent Prevot; Carlos Dieguez; Javier Crespo; Gema Frühbeck; Maria L. Martinez-Chantar; Ruben Nogueiras

doi:10.1016/j.jhep.2020.09.027

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Marcos F. Fondevila, Maria Mercado-Gómez, Amaia Rodríguez, Maria J. Gonzalez-Rellan, Paula Iruzubieta, Víctor Valentí, Javier Escalada, Markus Schwaninger, Vincent Prevot, Carlos Dieguez, Javier Crespo, Gema Frühbeck, Maria L. Martinez-Chantar^*, Ruben Nogueiras

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

55 Citations (Scopus)

Original language	English
Journal	Journal of Hepatology
Volume	74
Issue number	2
Pages (from-to)	469-471
Number of pages	3
ISSN	0168-8278
DOIs	https://doi.org/10.1016/j.jhep.2020.09.027
Publication status	Published - 02.2021

Funding

This work has been supported by grants from FEDER/Ministerio de Ciencia, Innovaci?n y Universidades-Agencia Estatal de Investigaci?n (CD: BFU2017-87721; RN: RTI2018-099413-B-I00; MLMC: SAF2017-87301-R; Xunta de Galicia (RN: 2015-CP080 and 2016-PG057) and ED431G 2019/02, Fundaci?n BBVA (RN and MLM), Fundaci?n Atresmedia (RN), and European Foundation for the Study of Diabetes (RN). FIS: PI18/0130. Immunomediatd Nonalcoholic SteaTohepatItis; prevalence and CharacTerization. INSTInCT study (PI: Javier Crespo). Intensificaci?n IDIVAL I-1 (Javier Crespo). The research leading to these results has also received funding from the European Community's H2020 Framework Programme under the following grant: ERC Synergy Grant-2019-WATCH- 810331 to MS, VP and RN. CIBERobn and CIBERehd are initiatives of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644).

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Coronavirus related work

Research on SARS-CoV-2 / COVID-19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jhep.2020.09.027

Cite this

Fondevila, M. F., Mercado-Gómez, M., Rodríguez, A., Gonzalez-Rellan, M. J., Iruzubieta, P., Valentí, V., Escalada, J., Schwaninger, M., Prevot, V., Dieguez, C., Crespo, J., Frühbeck, G., Martinez-Chantar, M. L., & Nogueiras, R. (2021). Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points. Journal of Hepatology, 74(2), 469-471. https://doi.org/10.1016/j.jhep.2020.09.027

@article{de8e4f78291b4b489774d5d0a5552ec2,

title = "Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points",

author = "Fondevila, \{Marcos F.\} and Maria Mercado-G{\'o}mez and Amaia Rodr{\'i}guez and Gonzalez-Rellan, \{Maria J.\} and Paula Iruzubieta and V{\'i}ctor Valent{\'i} and Javier Escalada and Markus Schwaninger and Vincent Prevot and Carlos Dieguez and Javier Crespo and Gema Fr{\"u}hbeck and Martinez-Chantar, \{Maria L.\} and Ruben Nogueiras",

note = "Funding Information: This work has been supported by grants from FEDER/Ministerio de Ciencia, Innovaci?n y Universidades-Agencia Estatal de Investigaci?n (CD: BFU2017-87721; RN: RTI2018-099413-B-I00; MLMC: SAF2017-87301-R; Xunta de Galicia (RN: 2015-CP080 and 2016-PG057) and ED431G 2019/02, Fundaci?n BBVA (RN and MLM), Fundaci?n Atresmedia (RN), and European Foundation for the Study of Diabetes (RN). FIS: PI18/0130. Immunomediatd Nonalcoholic SteaTohepatItis; prevalence and CharacTerization. INSTInCT study (PI: Javier Crespo). Intensificaci?n IDIVAL I-1 (Javier Crespo). The research leading to these results has also received funding from the European Community's H2020 Framework Programme under the following grant: ERC Synergy Grant-2019-WATCH- 810331 to MS, VP and RN. CIBERobn and CIBERehd are initiatives of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = feb,

doi = "10.1016/j.jhep.2020.09.027",

language = "English",

volume = "74",

pages = "469--471",

journal = "Journal of Hepatology",

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Fondevila, MF, Mercado-Gómez, M, Rodríguez, A, Gonzalez-Rellan, MJ, Iruzubieta, P, Valentí, V, Escalada, J, Schwaninger, M, Prevot, V, Dieguez, C, Crespo, J, Frühbeck, G, Martinez-Chantar, ML & Nogueiras, R 2021, 'Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points', Journal of Hepatology, vol. 74, no. 2, pp. 469-471. https://doi.org/10.1016/j.jhep.2020.09.027

TY - JOUR

T1 - Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

AU - Fondevila, Marcos F.

AU - Mercado-Gómez, Maria

AU - Rodríguez, Amaia

AU - Gonzalez-Rellan, Maria J.

AU - Iruzubieta, Paula

AU - Valentí, Víctor

AU - Escalada, Javier

AU - Schwaninger, Markus

AU - Prevot, Vincent

AU - Dieguez, Carlos

AU - Crespo, Javier

AU - Frühbeck, Gema

AU - Martinez-Chantar, Maria L.

AU - Nogueiras, Ruben

N1 - Funding Information: This work has been supported by grants from FEDER/Ministerio de Ciencia, Innovaci?n y Universidades-Agencia Estatal de Investigaci?n (CD: BFU2017-87721; RN: RTI2018-099413-B-I00; MLMC: SAF2017-87301-R; Xunta de Galicia (RN: 2015-CP080 and 2016-PG057) and ED431G 2019/02, Fundaci?n BBVA (RN and MLM), Fundaci?n Atresmedia (RN), and European Foundation for the Study of Diabetes (RN). FIS: PI18/0130. Immunomediatd Nonalcoholic SteaTohepatItis; prevalence and CharacTerization. INSTInCT study (PI: Javier Crespo). Intensificaci?n IDIVAL I-1 (Javier Crespo). The research leading to these results has also received funding from the European Community's H2020 Framework Programme under the following grant: ERC Synergy Grant-2019-WATCH- 810331 to MS, VP and RN. CIBERobn and CIBERehd are initiatives of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2

Y1 - 2021/2

UR - https://www.scopus.com/pages/publications/85097384624

UR - https://www.mendeley.com/catalogue/b59ed5db-891a-32e5-b379-462ea30605eb/

U2 - 10.1016/j.jhep.2020.09.027

DO - 10.1016/j.jhep.2020.09.027

M3 - Letters

C2 - 33096086

AN - SCOPUS:85097384624

SN - 0168-8278

VL - 74

SP - 469

EP - 471

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 2

ER -

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Funding

Research Areas and Centers

Coronavirus related work

UN SDGs

Access to Document

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Cite this