Nutzenanalyse onkologischer Zentrenbildung im Bereich der Behandlung des kolorektalen Karzinoms

Translated title of the contribution: Utility Analysis of Oncological Centre Building in the Field of Colorectal Cancer

Ines Weinhold, Tobias Keck, Axel Merseburger, Achim Rody, Barbara Wollenberg, Danny Wende, Dennis Häckl, Christian Elsner*

*Corresponding author for this work


Background In the field of colorectal cancer and other cancer entities, there is an ongoing trend to establish multidisciplinary treatment in specialised cancer centres. Little is known by now about the outcomes of this centralised and quality-driven treatment approach. In light of the increasing cost-benefit discussions, assessments of their impact seem to be necessary. This paper discusses positive effects of cancer centres with a particular focus on the multidisciplinary approach and its potential impact on survival outcomes of colorectal cancer patients. The study applies a Markov approach to assess the epidemiological impact of the cancer centre establishment and associated life years gained, both at a regional level and over time. Materials and Methods We conducted a systematic literature review to evaluate effects of multidisciplinary treatment in specialised cancer centres in the field of colorectal cancer. Applying the PRISMA scheme, 602 articles were assessed by title, abstract and full text. Finally, 10 publications met the inclusion criteria and were included in a meta-analysis. Using the example of the Krebszentrum Nord at the University Hospital in the federal state of Schleswig-Holstein, we assessed the impact of changes in survival rates at the regional level by simulating expected incidence, mortality and prevalence rates in a Markov model including detailed population data of Schleswig-Holstein. Results The meta-analysis revealed that multidisciplinary treatment in a cancer centre was associated with a 4.5% reduction of mortality rates in colorectal cancer patients. The greatest benefits were found for patients in advanced disease stages. At the regional level, 106 life years could be gained through the centre for colorectal cancer until 2020, according to the assumptions of the simulation. Conclusion The establishment of colorectal cancer centres is associated with positive outcomes for patients. However, the scarce evidence base underpins the need for additional studies to further examine the impact of centre building in colorectal cancer care. Cancer registries are a solid foundation for further research. Future requirements for oncological care can be derived from the predicted epidemiological development.

Translated title of the contributionUtility Analysis of Oncological Centre Building in the Field of Colorectal Cancer
Original languageGerman
JournalZentralblatt fur Chirurgie - Zeitschrift fur Allgemeine, Viszeral- und Gefäßchirurgie
Issue number2
Pages (from-to)181-192
Number of pages12
Publication statusPublished - 01.04.2018

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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