TY - JOUR
T1 - Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer
AU - Gerdan, Lavinia
AU - Šegedin, Barbara
AU - Veninga, Theo
AU - Schild, Steven E.
AU - Rades, Dirk
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/9
Y1 - 2013/9
N2 - Background/Aim: To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC). Patients and Methods: Data of 155 patients receiving wholebrain radiotherapy (WBRT) alone for brain metastasis from SCLC were retrospectively evaluated. In addition to the number of involved extracranial organs, six potential prognostic factors were analyzed including WBRT regimen, age, gender, Karnofsky performance score (KPS), number of brain metastases, and interval from diagnosis of SCLC to WBRT. Results: Six-month survival rates of patients with involvement of 0, 1, 2, and ≥3 extracranial organs were 52%, 29%, 9%, and 0%, respectively (p<0.001). On multivariate analysis, the number of involved extracranial organs remained significant (p=0.003). Older age (p=0.005), lower KPS (p<0.001), and greater number of brain metastases (p=0.005) were also significantly associated with poorer survival. Conclusion: The number of involved extracranial organs is an independent prognostic factor of survival in SCLC patients with brain metastasis.
AB - Background/Aim: To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC). Patients and Methods: Data of 155 patients receiving wholebrain radiotherapy (WBRT) alone for brain metastasis from SCLC were retrospectively evaluated. In addition to the number of involved extracranial organs, six potential prognostic factors were analyzed including WBRT regimen, age, gender, Karnofsky performance score (KPS), number of brain metastases, and interval from diagnosis of SCLC to WBRT. Results: Six-month survival rates of patients with involvement of 0, 1, 2, and ≥3 extracranial organs were 52%, 29%, 9%, and 0%, respectively (p<0.001). On multivariate analysis, the number of involved extracranial organs remained significant (p=0.003). Older age (p=0.005), lower KPS (p<0.001), and greater number of brain metastases (p=0.005) were also significantly associated with poorer survival. Conclusion: The number of involved extracranial organs is an independent prognostic factor of survival in SCLC patients with brain metastasis.
UR - http://www.scopus.com/inward/record.url?scp=84885002613&partnerID=8YFLogxK
M3 - Journal articles
C2 - 24023324
AN - SCOPUS:84885002613
SN - 0250-7005
VL - 33
SP - 3887
EP - 3890
JO - Anticancer Research
JF - Anticancer Research
IS - 9
ER -
