Novel roles of complement in T effector cell regulation

Peter S. Heeger, Claudia Kemper*

*Corresponding author for this work
73 Citations (Scopus)


Our understanding of the complement system has markedly evolved from its early beginnings as a protein system merely detecting and tagging a pathogen for further clearance. For example, the repertoire of danger that complement recognizes covers currently a wide range of distinct self and non-self danger signals. Further, complement is now firmly established as instructor of adaptive B and T cell immunity. This review focuses on two the recent emerging paradigms in the field. Firstly, that complement is not only vitally required for the induction of Th1 immunity but also for the timely contraction of this protective response and therefore for prevention of autoimmunity and immune homeostasis. Secondly, that local rather than systemic complement is impacting on immunemodulation during a T cell response.

Original languageEnglish
Issue number2
Pages (from-to)216-224
Number of pages9
Publication statusPublished - 02.2012

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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