TY - JOUR
T1 - Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females
AU - Hecker, M.
AU - Bohnert, A.
AU - König, I. R.
AU - Bein, G.
AU - Hackstein, Holger
N1 - Funding Information:
This work was supported by grants from the Bundesministerium für Bildung und Forschung, Germany (NGFN IE-S08T03). H Hackstein is supported by a scholarship of the Stiftung Hämother-apie-Forschung, Bonn, Germany.
PY - 2003/4
Y1 - 2003/4
N2 - The interleukin-21 receptor (IL21R) was recently discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL21R shows strong sequence homologies to the interleukin-4 receptor α chain gene (IL4RA). In addition, both genes are adjacent and share structural similarity. We analyzed all the exons of the human IL21R gene and its 5′ flanking region for sequence variation. We identified four novel single nucleotide polymorphisms (SNPs) and genotyped 300 healthy blood donors. Total serum IgE levels were measured in all subjects and associated with IL21R SNPs. Results revealed a significant association of one IL21R polymorphism (T-83C) with elevated IgE levels (>100 kU/I) in females (OR = 3.000, CI- [1.163;8.385], P = 0.015, n = 138). This was confirmed in a second prospectively collected group of female blood donors (OR = 2.535, CI = [0.927;6.733], P = 0.046, n = 123). In contrast, no effects were observed in male subjects in either population. These findings identify IL21R as a possible novel target locus influencing IgE synthesis in female individuals.
AB - The interleukin-21 receptor (IL21R) was recently discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL21R shows strong sequence homologies to the interleukin-4 receptor α chain gene (IL4RA). In addition, both genes are adjacent and share structural similarity. We analyzed all the exons of the human IL21R gene and its 5′ flanking region for sequence variation. We identified four novel single nucleotide polymorphisms (SNPs) and genotyped 300 healthy blood donors. Total serum IgE levels were measured in all subjects and associated with IL21R SNPs. Results revealed a significant association of one IL21R polymorphism (T-83C) with elevated IgE levels (>100 kU/I) in females (OR = 3.000, CI- [1.163;8.385], P = 0.015, n = 138). This was confirmed in a second prospectively collected group of female blood donors (OR = 2.535, CI = [0.927;6.733], P = 0.046, n = 123). In contrast, no effects were observed in male subjects in either population. These findings identify IL21R as a possible novel target locus influencing IgE synthesis in female individuals.
UR - http://www.scopus.com/inward/record.url?scp=0346116791&partnerID=8YFLogxK
U2 - 10.1038/sj.gene.6363954
DO - 10.1038/sj.gene.6363954
M3 - Journal articles
C2 - 12700598
AN - SCOPUS:0346116791
SN - 1466-4879
VL - 4
SP - 228
EP - 233
JO - Genes and Immunity
JF - Genes and Immunity
IS - 3
ER -
