Norepinephrine Release Is Reduced by I1-Receptors in Addition to α2-Adrenoceptors

Walter Raasch*, Britta Jungbluth, Ulrich Schäfer, Walter Häuser, Peter Dominiak

*Corresponding author for this work
8 Citations (Scopus)


In pithed spontaneous hypertensive rats, noradrenaline overflow was diminished by moxonidine even when α2-adrenoceptors were blocked quantitatively using phenoxybenzamine, suggesting an I1-receptor- mediated mechanism of noradrenaline release. This hypothesis was confirmed, since the noradrenaline overflow was (1) increased under α2-adrenoceptors blockade by the mixed I12-antagonists efaroxan or idazoxan, (2) still reduced by moxonidine when both α2- and I1-receptors were blocked, and (3) diminished by agmatine after pretreatment with phenoxybenzamine, but not with AGN192403. An indirect ganglionic I1-receptor-mediated mechanism of noradrenaline release is supposed.

Original languageEnglish
JournalAnnals of the New York Academy of Sciences
Pages (from-to)270-273
Number of pages4
Publication statusPublished - 01.01.2003

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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