Norepinephrine amplifies effects of vasopressin on the isolated rat heart

Inge Derad; Peter Pauschinger; Jan Born

doi:10.1016/0167-0115(92)90006-G

Norepinephrine amplifies effects of vasopressin on the isolated rat heart

Inge Derad, Peter Pauschinger, Jan Born^*

^*Corresponding author for this work

Clinic of Internal Medicine I

1 Citation (Scopus)

Abstract

We compared effects of perfusion of norepinephrine (NE, 10^-9 mol 1^-1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%, P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%, P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O₂ ml^-1 g^-1, P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.

Original language	English
Journal	Regulatory Peptides
Volume	39
Issue number	1
Pages (from-to)	35-41
Number of pages	7
ISSN	0167-0115
DOIs	https://doi.org/10.1016/0167-0115(92)90006-G
Publication status	Published - 29.04.1992

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title = "Norepinephrine amplifies effects of vasopressin on the isolated rat heart",

abstract = "We compared effects of perfusion of norepinephrine (NE, 10-9 mol 1-1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%, P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%, P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O2 ml-1 g-1, P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.",

author = "Inge Derad and Peter Pauschinger and Jan Born",

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T1 - Norepinephrine amplifies effects of vasopressin on the isolated rat heart

AU - Derad, Inge

AU - Pauschinger, Peter

AU - Born, Jan

PY - 1992/4/29

Y1 - 1992/4/29

N2 - We compared effects of perfusion of norepinephrine (NE, 10-9 mol 1-1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%, P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%, P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O2 ml-1 g-1, P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.

AB - We compared effects of perfusion of norepinephrine (NE, 10-9 mol 1-1) and of unchanged Krebs-Henseleit solution on the cardiac response to bolus injection of arginine vasopressin (AVP, 2 ng). 14 isolated rat working heart preparations were used in a balanced cross-over design. Coronary flow, oxygen consumption and extraction, heart rate and total flow were continuously recorded. The concentration of NE was below that exerting per se systematic influences on cardiac activity. However, NE changed the cardiac response to AVP: (1) the AVP-induced reduction in coronary flow was greater during NE (mean: 41.7%) than vehicle perfusion (30.5%, P<0.005). (2) The AVP-induced decrease in oxygen consumption was stronger on top of the NE (41.5%) than vehicle perfusion (33.6%, P<0.005). (3) Following AVP, oxygen extraction during NE was increased compared to oxygen extraction during vehicle perfusion (3.61 ± 0.03 vs. 3.46 ± 0.02 μl O2 ml-1 g-1, P<0.005). Results support the view of a potentiating role of catecholamines for direct cardiovascular effects of AVP.

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VL - 39

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Norepinephrine amplifies effects of vasopressin on the isolated rat heart

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