No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit β3 in body weight regulation

A. Hinney, F. Geller, T. Neupert, C. Sommerlad, G. Gerber, T. Görg, W. Siegfried, H. Goldschmidt, H. Remschmidt, A. Ziegler, J. Hebebrand

16 Citations (Scopus)


The 825-C/T polymorphism of the β3 subunit of the heterotrimeric G protein gene (GNB3) has been shown to be associated with essential hypertension in humans. Recently, it was also reported that the 825-T allele has a higher frequency in obese than non-obese hypertensives suggesting that the primary effect of this allele is on body weight. The association to hypertension might merely be a secondary effect of the higher weight of the respective allele carriers. - To investigate an involvement of the 825-Tallele in body weight regulation in young individuals, we evaluated allele frequencies in 440 extremely obese children and adolescents (82.9% had a body mass index [BMI] ≥99th percentile), 51 obese students (BMI ≥90th percentile), 110 normal weight students (BMI between 40th and 60th percentile) and 144 underweight students (BMI≤15th percentile). The study groups were genotyped by polymerase chain reaction with subsequent restriction fragment length polymorphism analysis (PCR-RFLP). The one-sided Yates- corrected x2-test and the Cochran-Armitage trend test for association were performed. Tests for association were negative. The 825-T allele frequencies were similar in the four study groups belonging to different weight ranges (extreme early onset obesity: 0.29; obesity: 0.28; normal weight: 0.35; underweight: 0.32). Similarly, genotype frequencies did not differ between the groups. We concluded that the 825-T allele of the GNB3 does not play a major role in weight regulation in German children, adolescents and young adults.

Original languageEnglish
JournalExperimental and Clinical Endocrinology and Diabetes
Issue number8
Pages (from-to)402-405
Number of pages4
Publication statusPublished - 2001


Dive into the research topics of 'No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit β3 in body weight regulation'. Together they form a unique fingerprint.

Cite this