No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) 7 receptor genes in obesity, underweight or anorexia nervosa

A. Hinney; H. Herrmann; T. Löhr; K. Rosenkranz; A. Ziegler; G. Lehmkuhl; F. Poustka; M. H. Schmidt; H. Mayer; W. Siegfried; H. Remschmidt; J. Hebebrand

doi:10.1038/sj.ijo.0800926

No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) ₇ receptor genes in obesity, underweight or anorexia nervosa

A. Hinney, H. Herrmann, T. Löhr, K. Rosenkranz, A. Ziegler, G. Lehmkuhl, F. Poustka, M. H. Schmidt, H. Mayer, W. Siegfried, H. Remschmidt, J. Hebebrand

Institute of Medical Biometry and Statistic

University of Marburg

31 Citations (Scopus)

Abstract

The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT(1Dβ) receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT₇ receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal P-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.

Original language	English
Journal	International Journal of Obesity
Volume	23
Issue number	7
Pages (from-to)	760-763
Number of pages	4
ISSN	0307-0565
DOIs	https://doi.org/10.1038/sj.ijo.0800926
Publication status	Published - 1999

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Hinney, A., Herrmann, H., Löhr, T., Rosenkranz, K., Ziegler, A., Lehmkuhl, G., Poustka, F., Schmidt, M. H., Mayer, H., Siegfried, W., Remschmidt, H., & Hebebrand, J. (1999). No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) ₇ receptor genes in obesity, underweight or anorexia nervosa. International Journal of Obesity, 23(7), 760-763. https://doi.org/10.1038/sj.ijo.0800926

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title = "No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) 7 receptor genes in obesity, underweight or anorexia nervosa",

abstract = "The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT(1Dβ) receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal P-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.",

author = "A. Hinney and H. Herrmann and T. L{\"o}hr and K. Rosenkranz and A. Ziegler and G. Lehmkuhl and F. Poustka and Schmidt, {M. H.} and H. Mayer and W. Siegfried and H. Remschmidt and J. Hebebrand",

note = "Funding Information: We thank all probands for their participation. The cooperation of the employees of the Children's Hospital Hochried in Murnau and the Obesity Treatment Center in Berchtesgaden are gratefully acknowledged. This work was supported by the Deutsche For-schungsgemeinschaft.",

year = "1999",

doi = "10.1038/sj.ijo.0800926",

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Hinney, A, Herrmann, H, Löhr, T, Rosenkranz, K, Ziegler, A, Lehmkuhl, G, Poustka, F, Schmidt, MH, Mayer, H, Siegfried, W, Remschmidt, H & Hebebrand, J 1999, 'No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) ₇ receptor genes in obesity, underweight or anorexia nervosa', International Journal of Obesity, vol. 23, no. 7, pp. 760-763. https://doi.org/10.1038/sj.ijo.0800926

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T1 - No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) 7 receptor genes in obesity, underweight or anorexia nervosa

AU - Hinney, A.

AU - Herrmann, H.

AU - Löhr, T.

AU - Rosenkranz, K.

AU - Ziegler, A.

AU - Lehmkuhl, G.

AU - Poustka, F.

AU - Schmidt, M. H.

AU - Mayer, H.

AU - Siegfried, W.

AU - Remschmidt, H.

AU - Hebebrand, J.

N1 - Funding Information: We thank all probands for their participation. The cooperation of the employees of the Children's Hospital Hochried in Murnau and the Obesity Treatment Center in Berchtesgaden are gratefully acknowledged. This work was supported by the Deutsche For-schungsgemeinschaft.

PY - 1999

Y1 - 1999

N2 - The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT(1Dβ) receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal P-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.

AB - The serotonergic (5-hydroxytryptamine, 5-HT) system has been implicated in body weight regulation and in the etiology of anorexia nervosa (AN). Here we describe the screening of the known Phe-124-Cys polymorphism in the 5-HT(1Dβ) receptor gene and of the known Pro-279-Leu polymorphism in the 5-HT7 receptor gene. For association tests allele frequencies were compared between up to 393 extremely obese children and adolescents, 142 underweight students and 84 patients with AN. None of the association tests revealed nominal P-values below 0.3. We conclude that a major role of the investigated polymorphisms in body weight regulation or AN appears unlikely.

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No evidence for an involvement of alleles of polymorphisms in the serotonin(1Dβ) (and) ₇ receptor genes in obesity, underweight or anorexia nervosa

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