No correlation between two-dimensional measurements and three-dimensional configuration of the pharyngeal upper airway space in cone-beam computed tomography

The aim of this study was to evaluate both the 2-dimensional (2D) and 3-dimensional (3D) configuration of the posterior airway space (PAS) in healthy 239 patients using cone-beam computed tomography (CBCT). In particular, we investigated the correlation between the 2D and 3D measurements in view of the potential impact on diagnosis of upper airway obstruction. The pharyngeal airway of each patient was studied at five levels: the level of the posterior nasal spine (PNS), the level of half-height of the PNS and the tip of the soft palate, the level of the tip of the soft palate, the level of the anterior–inferior point of the second vertebra, and at least the level of the top of the epiglottis. At each of these levels, the anterior–posterior dimension as well as the corresponding cross-sectional area was measured. Furthermore we measured the volume of the whole PAS between the first and the last level and compared it with the corresponding 2D values. Differences between genders and age effects were estimated in an analysis of covariance. P values <.05 were considered significant. Linear models were fitted to find the optimal formula to calculate the area or volume from measured distances. Limits of agreement were calculated as 2 ± residual standard deviations. We generated normal 2D and 3D values of the PAS for a normal population. In regard to age, no significant differences were observed. Significant differences were assessed between healthy males and females; however no correlation was observed between the obtained measurements in 2D axial view and the corresponding cross-sectional areas and mean volume in 3D view. In summary, radiologic imaging is a helpful tool to evaluate the airway space in patients with OSAS. However, drawing conclusions from 2D PAS imaging to assess 3D PAS configuration is not reliable, since there is no sufficient correlation between posterior–anterior distances and the corresponding cross-sectional areas.