No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: A case-control study

Annika Schäfer, Steffen Emmert*, Jochen Kruppa, Steffen Schubert, Mladen Tzvetkov, Rotraut Mössner, Kristian Reich, Carola Berking, Matthias Volkenandt, Claudia Pföhler, Michael P. Schön, Thomas Vogt, Inke R. König, Jörg Reichrath

*Corresponding author for this work
22 Citations (Scopus)

Abstract

Melanoma is one of the most aggressive human cancers. The vitaminDsystemcontributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related proteins (1α-hydroxylase [CYP27B1], 1,25(OH)2D-24hydroxylase [CYP24A1], vitamin D-binding protein [VDBP]) and cancer risk are scarce, especially with respect tomelanoma. Mainly VDR polymorphisms regarding melanoma risk and prognosis were examined although other vitamin D metabolism-related genes may also be crucial. In our hospital-based case-control study including 305 melanoma patients and 370 healthy controls single nucleotide polymorphisms in the genes CYP27B1 (rs4646536), CYP24A1 (rs927650), VDBP (rs1155563, rs7041), and VDR (rs757343, rs731236, rs2107301, rs7975232) were analyzed for their association with melanoma risk and prognosis. Except VDR rs731236 and VDR rs2107301, the other six polymorphisms have not been analyzed regarding melanoma before. To further improve the prevention as well as the treatment of melanoma, it is important to identify further genetic markers for melanoma risk as well as prognosis in addition to the crude phenotypic, demographic, and environmentalmarkers used in the clinic today. Apanel of genetic risk markers could help to better identify individuals at risk for melanoma development or worse prognosis. We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population.

Original languageEnglish
JournalArchives of Dermatological Research
Volume304
Issue number5
Pages (from-to)353-361
Number of pages9
ISSN0340-3696
DOIs
Publication statusPublished - 07.2012

Fingerprint

Dive into the research topics of 'No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: A case-control study'. Together they form a unique fingerprint.

Cite this