TY - JOUR
T1 - No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: A case-control study
AU - Schäfer, Annika
AU - Emmert, Steffen
AU - Kruppa, Jochen
AU - Schubert, Steffen
AU - Tzvetkov, Mladen
AU - Mössner, Rotraut
AU - Reich, Kristian
AU - Berking, Carola
AU - Volkenandt, Matthias
AU - Pföhler, Claudia
AU - Schön, Michael P.
AU - Vogt, Thomas
AU - König, Inke R.
AU - Reichrath, Jörg
N1 - Funding Information:
Acknowledgments We thank Petra Laspe and Antje Apel for invaluable technical assistance. This work was supported by grants from the German Cancer Aid (Deutsche Krebshilfe) and the Deutsche Forschungsgemeinschaft DFG (GRK1034).
PY - 2012/7
Y1 - 2012/7
N2 - Melanoma is one of the most aggressive human cancers. The vitaminDsystemcontributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related proteins (1α-hydroxylase [CYP27B1], 1,25(OH)2D-24hydroxylase [CYP24A1], vitamin D-binding protein [VDBP]) and cancer risk are scarce, especially with respect tomelanoma. Mainly VDR polymorphisms regarding melanoma risk and prognosis were examined although other vitamin D metabolism-related genes may also be crucial. In our hospital-based case-control study including 305 melanoma patients and 370 healthy controls single nucleotide polymorphisms in the genes CYP27B1 (rs4646536), CYP24A1 (rs927650), VDBP (rs1155563, rs7041), and VDR (rs757343, rs731236, rs2107301, rs7975232) were analyzed for their association with melanoma risk and prognosis. Except VDR rs731236 and VDR rs2107301, the other six polymorphisms have not been analyzed regarding melanoma before. To further improve the prevention as well as the treatment of melanoma, it is important to identify further genetic markers for melanoma risk as well as prognosis in addition to the crude phenotypic, demographic, and environmentalmarkers used in the clinic today. Apanel of genetic risk markers could help to better identify individuals at risk for melanoma development or worse prognosis. We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population.
AB - Melanoma is one of the most aggressive human cancers. The vitaminDsystemcontributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related proteins (1α-hydroxylase [CYP27B1], 1,25(OH)2D-24hydroxylase [CYP24A1], vitamin D-binding protein [VDBP]) and cancer risk are scarce, especially with respect tomelanoma. Mainly VDR polymorphisms regarding melanoma risk and prognosis were examined although other vitamin D metabolism-related genes may also be crucial. In our hospital-based case-control study including 305 melanoma patients and 370 healthy controls single nucleotide polymorphisms in the genes CYP27B1 (rs4646536), CYP24A1 (rs927650), VDBP (rs1155563, rs7041), and VDR (rs757343, rs731236, rs2107301, rs7975232) were analyzed for their association with melanoma risk and prognosis. Except VDR rs731236 and VDR rs2107301, the other six polymorphisms have not been analyzed regarding melanoma before. To further improve the prevention as well as the treatment of melanoma, it is important to identify further genetic markers for melanoma risk as well as prognosis in addition to the crude phenotypic, demographic, and environmentalmarkers used in the clinic today. Apanel of genetic risk markers could help to better identify individuals at risk for melanoma development or worse prognosis. We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population.
UR - http://www.scopus.com/inward/record.url?scp=84864754764&partnerID=8YFLogxK
U2 - 10.1007/s00403-012-1243-3
DO - 10.1007/s00403-012-1243-3
M3 - Journal articles
C2 - 22576141
AN - SCOPUS:84864754764
SN - 0340-3696
VL - 304
SP - 353
EP - 361
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
IS - 5
ER -