No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis

Dorothee Schweer; Marc Jacobsen; Andreas Ziegler; Steffi Jäkel; Wolfgang H. Oertel; Norbert Sommer; Bernhard Hemmer

doi:10.1016/S0165-5728(01)00347-2

No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis

Dorothee Schweer, Marc Jacobsen, Andreas Ziegler, Steffi Jäkel, Wolfgang H. Oertel, Norbert Sommer, Bernhard Hemmer^*

^*Corresponding author for this work

Institute of Medical Biometry and Statistic

University of Marburg

6 Citations (Scopus)

Abstract

Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivation of cytokines and modulation of antigen-mediated immune responses. Based on its role in inflammatory and neurodegenerative disorders, we investigated the role of A2M and its receptor low-density lipoprotein receptor-related protein (LRP) for the development of multiple sclerosis (MS). We analyzed the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del), and one polymorphism in the LRP (A216V) gene in a case control study involving 326 MS patients, and 290 controls, all defined for the expression of HLA-DR15. No association was found for any of the three polymorphism with MS. Furthermore, no differences in serum A2M levels were detected between MS patients and controls. The results do not suggest a contribution of A2M and LRP to the development of MS.

Original language	English
Journal	Journal of Neuroimmunology
Volume	118
Issue number	2
Pages (from-to)	300-303
Number of pages	4
ISSN	0165-5728
DOIs	https://doi.org/10.1016/S0165-5728(01)00347-2
Publication status	Published - 30.08.2001

Funding

We thank A. Hehenkamp, Prof. H.I. Schipper and Prof. S. Schuhmacher for support. The study was funded by the “Gemeinnützige Hertie-Stiftung” and Kempkes Stiftung. B.H. is a Heisenberg-Fellow of the Deutsche Forschungsgemeinschaft.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0165-5728(01)00347-2

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title = "No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis",

abstract = "Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivation of cytokines and modulation of antigen-mediated immune responses. Based on its role in inflammatory and neurodegenerative disorders, we investigated the role of A2M and its receptor low-density lipoprotein receptor-related protein (LRP) for the development of multiple sclerosis (MS). We analyzed the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del), and one polymorphism in the LRP (A216V) gene in a case control study involving 326 MS patients, and 290 controls, all defined for the expression of HLA-DR15. No association was found for any of the three polymorphism with MS. Furthermore, no differences in serum A2M levels were detected between MS patients and controls. The results do not suggest a contribution of A2M and LRP to the development of MS.",

author = "Dorothee Schweer and Marc Jacobsen and Andreas Ziegler and Steffi J{\"a}kel and Oertel, \{Wolfgang H.\} and Norbert Sommer and Bernhard Hemmer",

note = "Funding Information: We thank A. Hehenkamp, Prof. H.I. Schipper and Prof. S. Schuhmacher for support. The study was funded by the “Gemeinn{\"u}tzige Hertie-Stiftung” and Kempkes Stiftung. B.H. is a Heisenberg-Fellow of the Deutsche Forschungsgemeinschaft.",

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T1 - No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis

AU - Schweer, Dorothee

AU - Jacobsen, Marc

AU - Ziegler, Andreas

AU - Jäkel, Steffi

AU - Oertel, Wolfgang H.

AU - Sommer, Norbert

AU - Hemmer, Bernhard

N1 - Funding Information: We thank A. Hehenkamp, Prof. H.I. Schipper and Prof. S. Schuhmacher for support. The study was funded by the “Gemeinnützige Hertie-Stiftung” and Kempkes Stiftung. B.H. is a Heisenberg-Fellow of the Deutsche Forschungsgemeinschaft.

PY - 2001/8/30

Y1 - 2001/8/30

N2 - Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivation of cytokines and modulation of antigen-mediated immune responses. Based on its role in inflammatory and neurodegenerative disorders, we investigated the role of A2M and its receptor low-density lipoprotein receptor-related protein (LRP) for the development of multiple sclerosis (MS). We analyzed the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del), and one polymorphism in the LRP (A216V) gene in a case control study involving 326 MS patients, and 290 controls, all defined for the expression of HLA-DR15. No association was found for any of the three polymorphism with MS. Furthermore, no differences in serum A2M levels were detected between MS patients and controls. The results do not suggest a contribution of A2M and LRP to the development of MS.

AB - Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivation of cytokines and modulation of antigen-mediated immune responses. Based on its role in inflammatory and neurodegenerative disorders, we investigated the role of A2M and its receptor low-density lipoprotein receptor-related protein (LRP) for the development of multiple sclerosis (MS). We analyzed the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del), and one polymorphism in the LRP (A216V) gene in a case control study involving 326 MS patients, and 290 controls, all defined for the expression of HLA-DR15. No association was found for any of the three polymorphism with MS. Furthermore, no differences in serum A2M levels were detected between MS patients and controls. The results do not suggest a contribution of A2M and LRP to the development of MS.

UR - https://www.scopus.com/pages/publications/0035975223

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DO - 10.1016/S0165-5728(01)00347-2

M3 - Journal articles

C2 - 11498265

AN - SCOPUS:0035975223

SN - 0165-5728

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EP - 303

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 2

ER -

No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis

Abstract

Funding

UN SDGs

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