TY - JOUR
T1 - No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis
AU - Schweer, Dorothee
AU - Jacobsen, Marc
AU - Ziegler, Andreas
AU - Jäkel, Steffi
AU - Oertel, Wolfgang H.
AU - Sommer, Norbert
AU - Hemmer, Bernhard
N1 - Funding Information:
We thank A. Hehenkamp, Prof. H.I. Schipper and Prof. S. Schuhmacher for support. The study was funded by the “Gemeinnützige Hertie-Stiftung” and Kempkes Stiftung. B.H. is a Heisenberg-Fellow of the Deutsche Forschungsgemeinschaft.
PY - 2001/8/30
Y1 - 2001/8/30
N2 - Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivation of cytokines and modulation of antigen-mediated immune responses. Based on its role in inflammatory and neurodegenerative disorders, we investigated the role of A2M and its receptor low-density lipoprotein receptor-related protein (LRP) for the development of multiple sclerosis (MS). We analyzed the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del), and one polymorphism in the LRP (A216V) gene in a case control study involving 326 MS patients, and 290 controls, all defined for the expression of HLA-DR15. No association was found for any of the three polymorphism with MS. Furthermore, no differences in serum A2M levels were detected between MS patients and controls. The results do not suggest a contribution of A2M and LRP to the development of MS.
AB - Alpha-2-macroglobulin (A2M) is a proteinase inhibitor involved in deactivation of cytokines and modulation of antigen-mediated immune responses. Based on its role in inflammatory and neurodegenerative disorders, we investigated the role of A2M and its receptor low-density lipoprotein receptor-related protein (LRP) for the development of multiple sclerosis (MS). We analyzed the frequency of two polymorphisms in the A2M (Val 1000 Ile, Exon 18 del), and one polymorphism in the LRP (A216V) gene in a case control study involving 326 MS patients, and 290 controls, all defined for the expression of HLA-DR15. No association was found for any of the three polymorphism with MS. Furthermore, no differences in serum A2M levels were detected between MS patients and controls. The results do not suggest a contribution of A2M and LRP to the development of MS.
UR - http://www.scopus.com/inward/record.url?scp=0035975223&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(01)00347-2
DO - 10.1016/S0165-5728(01)00347-2
M3 - Journal articles
C2 - 11498265
AN - SCOPUS:0035975223
SN - 0165-5728
VL - 118
SP - 300
EP - 303
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 2
ER -
