No association between brain-derived neurotrophic factor g196a polymorphism and clinical features of parkinson's disease

Marina Svetel; Tatjana Pekmezovic; Vladana Markovic; Ivana Novaković; Valerija Dobričić; Gordana Djuric; Elka Stefanova; Vladimir Kostić

doi:10.1159/000352033

No association between brain-derived neurotrophic factor g196a polymorphism and clinical features of parkinson's disease

Marina Svetel, Tatjana Pekmezovic, Vladana Markovic, Ivana Novaković, Valerija Dobričić, Gordana Djuric, Elka Stefanova, Vladimir Kostić

Institute of Neurogenetics

University of Belgrade

22 Citations (Scopus)

Abstract

Aims: To investigate association of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene with clinical features in Serbian patients with Parkinson's disease (PD). Methods: The study comprised 177 consecutive PD patients. A comprehensive set of clinical scales was applied in all patients. The controls (n = 366) were recruited among students. Single nucleotide polymorphisms (SNPs; rs6265) were analyzed using TaqMan assays. Results: PD patients (118 males) were aged 58.9 ± 10.9 years, with a mean age at onset of 49.0 ± 11.2 years. PD patients and controls had a similar distribution of genotypes and allele frequencies. The presence of the Met allele did not influence the clinical characteristics of PD patients (age at onset, family history, gender, disease duration, form of the disease, initial symptoms, cognitive abilities, depression, anxiety, disease severity, severity of motor and prevalence of nonmotor symptoms, and development of motor complications). Conclusion: Overall, the Val66Met polymorphism did not modify the clinical features in PD patients.

Original language	English
Journal	European Neurology
Volume	70
Issue number	5-6
Pages (from-to)	257-262
Number of pages	6
ISSN	0014-3022
DOIs	https://doi.org/10.1159/000352033
Publication status	Published - 12.2013

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@article{f4c5cf7e0dc74562b2f1d7c4aa69ffde,

title = "No association between brain-derived neurotrophic factor g196a polymorphism and clinical features of parkinson's disease",

abstract = "Aims: To investigate association of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene with clinical features in Serbian patients with Parkinson's disease (PD). Methods: The study comprised 177 consecutive PD patients. A comprehensive set of clinical scales was applied in all patients. The controls (n = 366) were recruited among students. Single nucleotide polymorphisms (SNPs; rs6265) were analyzed using TaqMan assays. Results: PD patients (118 males) were aged 58.9 ± 10.9 years, with a mean age at onset of 49.0 ± 11.2 years. PD patients and controls had a similar distribution of genotypes and allele frequencies. The presence of the Met allele did not influence the clinical characteristics of PD patients (age at onset, family history, gender, disease duration, form of the disease, initial symptoms, cognitive abilities, depression, anxiety, disease severity, severity of motor and prevalence of nonmotor symptoms, and development of motor complications). Conclusion: Overall, the Val66Met polymorphism did not modify the clinical features in PD patients.",

author = "Marina Svetel and Tatjana Pekmezovic and Vladana Markovic and Ivana Novakovi{\'c} and Valerija Dobri{\v c}i{\'c} and Gordana Djuric and Elka Stefanova and Vladimir Kosti{\'c}",

year = "2013",

month = dec,

doi = "10.1159/000352033",

language = "English",

volume = "70",

pages = "257--262",

journal = "European Neurology",

issn = "0014-3022",

number = "5-6",

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TY - JOUR

T1 - No association between brain-derived neurotrophic factor g196a polymorphism and clinical features of parkinson's disease

AU - Svetel, Marina

AU - Pekmezovic, Tatjana

AU - Markovic, Vladana

AU - Novaković, Ivana

AU - Dobričić, Valerija

AU - Djuric, Gordana

AU - Stefanova, Elka

AU - Kostić, Vladimir

PY - 2013/12

Y1 - 2013/12

N2 - Aims: To investigate association of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene with clinical features in Serbian patients with Parkinson's disease (PD). Methods: The study comprised 177 consecutive PD patients. A comprehensive set of clinical scales was applied in all patients. The controls (n = 366) were recruited among students. Single nucleotide polymorphisms (SNPs; rs6265) were analyzed using TaqMan assays. Results: PD patients (118 males) were aged 58.9 ± 10.9 years, with a mean age at onset of 49.0 ± 11.2 years. PD patients and controls had a similar distribution of genotypes and allele frequencies. The presence of the Met allele did not influence the clinical characteristics of PD patients (age at onset, family history, gender, disease duration, form of the disease, initial symptoms, cognitive abilities, depression, anxiety, disease severity, severity of motor and prevalence of nonmotor symptoms, and development of motor complications). Conclusion: Overall, the Val66Met polymorphism did not modify the clinical features in PD patients.

AB - Aims: To investigate association of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene with clinical features in Serbian patients with Parkinson's disease (PD). Methods: The study comprised 177 consecutive PD patients. A comprehensive set of clinical scales was applied in all patients. The controls (n = 366) were recruited among students. Single nucleotide polymorphisms (SNPs; rs6265) were analyzed using TaqMan assays. Results: PD patients (118 males) were aged 58.9 ± 10.9 years, with a mean age at onset of 49.0 ± 11.2 years. PD patients and controls had a similar distribution of genotypes and allele frequencies. The presence of the Met allele did not influence the clinical characteristics of PD patients (age at onset, family history, gender, disease duration, form of the disease, initial symptoms, cognitive abilities, depression, anxiety, disease severity, severity of motor and prevalence of nonmotor symptoms, and development of motor complications). Conclusion: Overall, the Val66Met polymorphism did not modify the clinical features in PD patients.

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U2 - 10.1159/000352033

DO - 10.1159/000352033

M3 - Journal articles

C2 - 24051673

AN - SCOPUS:84890498649

SN - 0014-3022

VL - 70

SP - 257

EP - 262

JO - European Neurology

JF - European Neurology

IS - 5-6

ER -

No association between brain-derived neurotrophic factor g196a polymorphism and clinical features of parkinson's disease

Abstract

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