TY - JOUR
T1 - NK cells
T2 - An attractive candidate for cancer therapy
AU - Valipour, Behnaz
AU - Velaei, Kobra
AU - Abedelahi, Ali
AU - Karimipour, Mohammad
AU - Darabi, Masoud
AU - Charoudeh, Hojjatollah Nozad
N1 - Funding Information:
The authors wish to thank staff of the Stem Cell Research Center, Tabriz University of Medical Sciences for kind help and support. This study was financially supported by the Stem Cell Research Center, Tabriz University of Medical sciences, Tabriz, Iran (Ph.D Thesis No: 94/5‐3/8 and ethical number: TBZMED.REC.1394.1065).
Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Natural killer (NK) cells have significant capability in tumor immune-surveillance. The ability of lyse transformed cells immediately in an antigen-independent manner make them an attractive candidate for cancer cell therapy. Despite employment of NK cells in cancer immunotherapy, clinical trials are faced with serious limitations such as trouble with the penetration of NK cells in tumor sites, limited in vivo persistence, and tumor microenvironment interference. Taken together, the NK-cell cancer therapy is still infant scenario that has a long way to be translated in clinic. Current article first reviews characteristic features of NK lymphocytes. Then, it discusses about important disruptive barriers and motivator in the developmental stages of NK cells like as tumor microenvironment. Finally, some revolutionary approaches are highlighted utilizing of NK cells in cancer therapy.
AB - Natural killer (NK) cells have significant capability in tumor immune-surveillance. The ability of lyse transformed cells immediately in an antigen-independent manner make them an attractive candidate for cancer cell therapy. Despite employment of NK cells in cancer immunotherapy, clinical trials are faced with serious limitations such as trouble with the penetration of NK cells in tumor sites, limited in vivo persistence, and tumor microenvironment interference. Taken together, the NK-cell cancer therapy is still infant scenario that has a long way to be translated in clinic. Current article first reviews characteristic features of NK lymphocytes. Then, it discusses about important disruptive barriers and motivator in the developmental stages of NK cells like as tumor microenvironment. Finally, some revolutionary approaches are highlighted utilizing of NK cells in cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85067360858&partnerID=8YFLogxK
U2 - 10.1002/jcp.28657
DO - 10.1002/jcp.28657
M3 - Scientific review articles
C2 - 30993712
AN - SCOPUS:85067360858
SN - 0021-9541
VL - 234
SP - 19352
EP - 19365
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 11
ER -
