Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort

Lorelei A. Mucci; Yudi Pawitan; Francesca Demichelis; Katja Fall; Jennifer R. Stark; Hans Olov Adami; Swen Olof Andersson; Ove Andrén; Anna S. Eisenstein; Lars Holmberg; Wei Huang; Philip W. Kantoff; Sven Perner; Meir J. Stampfer; Jan Erik Johansson; Mark A. Rubin

doi:10.1158/1055-9965.EPI-07-0722

Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort

Lorelei A. Mucci^*, Yudi Pawitan, Francesca Demichelis, Katja Fall, Jennifer R. Stark, Hans Olov Adami, Swen Olof Andersson, Ove Andrén, Anna S. Eisenstein, Lars Holmberg, Wei Huang, Philip W. Kantoff, Sven Perner, Meir J. Stampfer, Jan Erik Johansson, Mark A. Rubin

^*Corresponding author for this work

Institute of Pathology

8 Citations (Scopus)

Abstract

Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.

Original language	English
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	17
Issue number	1
Pages (from-to)	249-251
Number of pages	3
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-07-0722
Publication status	Published - 01.01.2008

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Mucci, L. A., Pawitan, Y., Demichelis, F., Fall, K., Stark, J. R., Adami, H. O., Andersson, S. O., Andrén, O., Eisenstein, A. S., Holmberg, L., Huang, W., Kantoff, P. W., Perner, S., Stampfer, M. J., Johansson, J. E., & Rubin, M. A. (2008). Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort. Cancer Epidemiology Biomarkers and Prevention, 17(1), 249-251. https://doi.org/10.1158/1055-9965.EPI-07-0722

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title = "Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort",

abstract = "Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.",

author = "Mucci, {Lorelei A.} and Yudi Pawitan and Francesca Demichelis and Katja Fall and Stark, {Jennifer R.} and Adami, {Hans Olov} and Andersson, {Swen Olof} and Ove Andr{\'e}n and Eisenstein, {Anna S.} and Lars Holmberg and Wei Huang and Kantoff, {Philip W.} and Sven Perner and Stampfer, {Meir J.} and Johansson, {Jan Erik} and Rubin, {Mark A.}",

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Mucci, LA, Pawitan, Y, Demichelis, F, Fall, K, Stark, JR, Adami, HO, Andersson, SO, Andrén, O, Eisenstein, AS, Holmberg, L, Huang, W, Kantoff, PW, Perner, S, Stampfer, MJ, Johansson, JE & Rubin, MA 2008, 'Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort', Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 1, pp. 249-251. https://doi.org/10.1158/1055-9965.EPI-07-0722

TY - JOUR

T1 - Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort

AU - Mucci, Lorelei A.

AU - Pawitan, Yudi

AU - Demichelis, Francesca

AU - Fall, Katja

AU - Stark, Jennifer R.

AU - Adami, Hans Olov

AU - Andersson, Swen Olof

AU - Andrén, Ove

AU - Eisenstein, Anna S.

AU - Holmberg, Lars

AU - Huang, Wei

AU - Kantoff, Philip W.

AU - Perner, Sven

AU - Stampfer, Meir J.

AU - Johansson, Jan Erik

AU - Rubin, Mark A.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.

AB - Tumor molecular markers hold promise to distinguish potentially lethal from indolent prostate cancer and to guide treatment choices. A previous study identified a nine-gene molecular signature in tumors associated with prostate-specific antigen relapse after prostatectomy. We examined this molecular model in relation to prostate cancer death among 172 men with initially localized disease. We quantified protein expression of the nine genes in tumors to classify progression risk. Accounting for clinical prognostic factors, the nine-gene model did not provide discrimination to predict lethal and indolent prostate cancer.

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U2 - 10.1158/1055-9965.EPI-07-0722

DO - 10.1158/1055-9965.EPI-07-0722

M3 - Journal articles

C2 - 18199732

AN - SCOPUS:38849165855

SN - 1055-9965

VL - 17

SP - 249

EP - 251

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 1

ER -

Nine-gene molecular signature is not associated with prostate cancer death in a watchful waiting cohort

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