The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter transgene, nuclear translocation of NF-κB in neurons and enhanced DNA binding of NF-κB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death- promoting role of NF-κB in focal ischemia. NF-κB may provide a new pharmacological target in neurologic disease.

Original languageEnglish
JournalNature Medicine
Issue number5
Pages (from-to)554-559
Number of pages6
Publication statusPublished - 01.05.1999

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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