New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann; Anika Großhennig; Peter S. Braund; Inke R. König; Christian Hengstenberg; Alistair S. Hall; Patrick Linsel-Nitschke; Sekar Kathiresan; Ben Wright; David Alexandre Trégouët; Francois Cambien; Petra Bruse; Zouhair Aherrahrou; Arnika K. Wagner; Klaus Stark; Stephen M. Schwartz; Veikko Salomaa; Roberto Elosua; Olle Melander; Benjamin F. Voight; Christopher J. O'Donnell; Leena Peltonen; David S. Siscovick; David Altshuler; Piera Angelica Merlini; Flora Peyvandi; Luisa Bernardinelli; Diego Ardissino; Arne Schillert; Stefan Blankenberg; Tanja Zeller; Philipp Wild; Daniel F. Schwarz; Laurence Tiret; Claire Perret; Stefan Schreiber; Nour Eddine El Mokhtari; Arne Schäfer; Winfried März; Wilfried Renner; Peter Bugert; Harald Klüter; Jürgen Schrezenmeir; Diana Rubin; Stephen G. Ball; Anthony J. Balmforth; H. Erich Wichmann; Thomas Meitinger; Marcus Fischer; Christa Meisinger; Jens Baumert; Annette Peters; Willem H. Ouwehand; Panos Deloukas; John R. Thompson; Andreas Ziegler; Nilesh J. Samani; Heribert Schunkert

doi:10.1038/ng.307

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann^*, Anika Großhennig, Peter S. Braund, Inke R. König, Christian Hengstenberg, Alistair S. Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K. Wagner, Klaus Stark, Stephen M. Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F. VoightChristopher J. O'Donnell, Leena Peltonen, David S. Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F. Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G. Ball, Anthony J. Balmforth, H. Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H. Ouwehand, Panos Deloukas, John R. Thompson, Andreas Ziegler, Nilesh J. Samani, Heribert Schunkert

^*Corresponding author for this work

Institute of Medical Biometry and Statistic

318 Citations (Scopus)

Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10^-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10^-7; OR = 1.08, 95% CI = 1.05-1.11).

Original language	English
Journal	Nature Genetics
Volume	41
Issue number	3
Pages (from-to)	280-282
Number of pages	3
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.307
Publication status	Published - 01.03.2009

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Erdmann, J., Großhennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Trégouët, D. A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., ... Schunkert, H. (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nature Genetics, 41(3), 280-282. https://doi.org/10.1038/ng.307

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title = "New susceptibility locus for coronary artery disease on chromosome 3q22.3",

abstract = "We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10-7; OR = 1.08, 95% CI = 1.05-1.11).",

author = "Jeanette Erdmann and Anika Gro{\ss}hennig and Braund, {Peter S.} and K{\"o}nig, {Inke R.} and Christian Hengstenberg and Hall, {Alistair S.} and Patrick Linsel-Nitschke and Sekar Kathiresan and Ben Wright and Tr{\'e}gou{\"e}t, {David Alexandre} and Francois Cambien and Petra Bruse and Zouhair Aherrahrou and Wagner, {Arnika K.} and Klaus Stark and Schwartz, {Stephen M.} and Veikko Salomaa and Roberto Elosua and Olle Melander and Voight, {Benjamin F.} and O'Donnell, {Christopher J.} and Leena Peltonen and Siscovick, {David S.} and David Altshuler and Merlini, {Piera Angelica} and Flora Peyvandi and Luisa Bernardinelli and Diego Ardissino and Arne Schillert and Stefan Blankenberg and Tanja Zeller and Philipp Wild and Schwarz, {Daniel F.} and Laurence Tiret and Claire Perret and Stefan Schreiber and Mokhtari, {Nour Eddine El} and Arne Sch{\"a}fer and Winfried M{\"a}rz and Wilfried Renner and Peter Bugert and Harald Kl{\"u}ter and J{\"u}rgen Schrezenmeir and Diana Rubin and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Wichmann, {H. Erich} and Thomas Meitinger and Marcus Fischer and Christa Meisinger and Jens Baumert and Annette Peters and Ouwehand, {Willem H.} and Panos Deloukas and Thompson, {John R.} and Andreas Ziegler and Samani, {Nilesh J.} and Heribert Schunkert",

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Erdmann, J, Großhennig, A, Braund, PS, König, IR, Hengstenberg, C, Hall, AS, Linsel-Nitschke, P, Kathiresan, S, Wright, B, Trégouët, DA, Cambien, F, Bruse, P , Aherrahrou, Z , Wagner, AK, Stark, K, Schwartz, SM, Salomaa, V, Elosua, R, Melander, O, Voight, BF, O'Donnell, CJ, Peltonen, L, Siscovick, DS, Altshuler, D, Merlini, PA, Peyvandi, F, Bernardinelli, L, Ardissino, D, Schillert, A, Blankenberg, S, Zeller, T, Wild, P, Schwarz, DF, Tiret, L, Perret, C, Schreiber, S, Mokhtari, NEE, Schäfer, A, März, W, Renner, W, Bugert, P, Klüter, H, Schrezenmeir, J, Rubin, D, Ball, SG, Balmforth, AJ, Wichmann, HE, Meitinger, T, Fischer, M, Meisinger, C, Baumert, J, Peters, A, Ouwehand, WH, Deloukas, P, Thompson, JR, Ziegler, A, Samani, NJ & Schunkert, H 2009, 'New susceptibility locus for coronary artery disease on chromosome 3q22.3', Nature Genetics, vol. 41, no. 3, pp. 280-282. https://doi.org/10.1038/ng.307

TY - JOUR

T1 - New susceptibility locus for coronary artery disease on chromosome 3q22.3

AU - Erdmann, Jeanette

AU - Großhennig, Anika

AU - Braund, Peter S.

AU - König, Inke R.

AU - Hengstenberg, Christian

AU - Hall, Alistair S.

AU - Linsel-Nitschke, Patrick

AU - Kathiresan, Sekar

AU - Wright, Ben

AU - Trégouët, David Alexandre

AU - Cambien, Francois

AU - Bruse, Petra

AU - Aherrahrou, Zouhair

AU - Wagner, Arnika K.

AU - Stark, Klaus

AU - Schwartz, Stephen M.

AU - Salomaa, Veikko

AU - Elosua, Roberto

AU - Melander, Olle

AU - Voight, Benjamin F.

AU - O'Donnell, Christopher J.

AU - Peltonen, Leena

AU - Siscovick, David S.

AU - Altshuler, David

AU - Merlini, Piera Angelica

AU - Peyvandi, Flora

AU - Bernardinelli, Luisa

AU - Ardissino, Diego

AU - Schillert, Arne

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Wild, Philipp

AU - Schwarz, Daniel F.

AU - Tiret, Laurence

AU - Perret, Claire

AU - Schreiber, Stefan

AU - Mokhtari, Nour Eddine El

AU - Schäfer, Arne

AU - März, Winfried

AU - Renner, Wilfried

AU - Bugert, Peter

AU - Klüter, Harald

AU - Schrezenmeir, Jürgen

AU - Rubin, Diana

AU - Ball, Stephen G.

AU - Balmforth, Anthony J.

AU - Wichmann, H. Erich

AU - Meitinger, Thomas

AU - Fischer, Marcus

AU - Meisinger, Christa

AU - Baumert, Jens

AU - Peters, Annette

AU - Ouwehand, Willem H.

AU - Deloukas, Panos

AU - Thompson, John R.

AU - Ziegler, Andreas

AU - Samani, Nilesh J.

AU - Schunkert, Heribert

PY - 2009/3/1

Y1 - 2009/3/1

N2 - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10-7; OR = 1.08, 95% CI = 1.05-1.11).

AB - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in ∼25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 × 10-13; OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 × 10-7; OR = 1.08, 95% CI = 1.05-1.11).

UR - http://www.scopus.com/inward/record.url?scp=61349177857&partnerID=8YFLogxK

U2 - 10.1038/ng.307

DO - 10.1038/ng.307

M3 - Journal articles

C2 - 19198612

AN - SCOPUS:61349177857

SN - 1061-4036

VL - 41

SP - 280

EP - 282

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

New susceptibility locus for coronary artery disease on chromosome 3q22.3

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New susceptibility locus for coronary artery disease on chromosome 3q22.3

Abstract

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