New members of the neurexin superfamily: Multiple rodent homologues of the human CASPR5 gene

Walther Traut*, Dieter Weichenhan, Heinz Himmelbauer, Heinz Winking

*Corresponding author for this work
18 Citations (Scopus)

Abstract

Proteins of the Caspr family are involved in cell contacts and communication in the nervous system. We identified and, by in silico reconstruction, compiled three orthologues of the human CASPR5 gene from the mouse genome, four from the rat genome, and one each from the chimpanzee, dog, opossum, and chicken genomes. Obviously, Caspr5 gene duplications have taken place during evolution of the rodent lineage. In the rat, the four paralogues are located in one chromosome arm, Chr 13p. In the mouse, however, the three Caspr5 genes are located in two chromosomes, Chr 1 and Chr 17. RT-PCR shows that all three mouse paralogues are being expressed. Common expression is found in brain tissue but different expression patterns are seen in other organs during fetal development and in the adult stage. Tissue specificity of expression has diverged during evolution of this young rodent gene family.

Original languageEnglish
JournalMammalian Genome
Volume17
Issue number7
Pages (from-to)723-731
Number of pages9
ISSN0938-8990
DOIs
Publication statusPublished - 01.07.2006

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