TY - JOUR
T1 - New jobs for an old enzyme: the revival of IDO
AU - von Bubnoff, Dagmar
AU - Koch, Susanne
AU - Bieber, Thomas
PY - 2003/6
Y1 - 2003/6
N2 - Unresponsiveness towards autoantigens or potentially harmful pathogens can be thought of as an active process of developing tolerance. The induction of this activity relies on the interaction of antigen-presenting cells (APCs) and T cells, causing T-cell tolerance. Very recently, a new feature of regulatory APCs was observed. The expression of indoleamine-2,3-dioxygenase (IDO) activity by certain dendritic cells (DCs), monocytes and macrophages has immunomodulatory effects on T cells that are related to the peri-cellular degradation of the essential amino acid tryptophan [ 1 ]. In their recent review, Grohmann and co-authors [ 2 ] described the central role of IDO in the control of T-cell activity during infection, pregnancy, autoimmunity, transplantation and neoplasia.
AB - Unresponsiveness towards autoantigens or potentially harmful pathogens can be thought of as an active process of developing tolerance. The induction of this activity relies on the interaction of antigen-presenting cells (APCs) and T cells, causing T-cell tolerance. Very recently, a new feature of regulatory APCs was observed. The expression of indoleamine-2,3-dioxygenase (IDO) activity by certain dendritic cells (DCs), monocytes and macrophages has immunomodulatory effects on T cells that are related to the peri-cellular degradation of the essential amino acid tryptophan [ 1 ]. In their recent review, Grohmann and co-authors [ 2 ] described the central role of IDO in the control of T-cell activity during infection, pregnancy, autoimmunity, transplantation and neoplasia.
UR - http://www.scopus.com/inward/record.url?scp=0042967963&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(03)00110-8
DO - 10.1016/S1471-4906(03)00110-8
M3 - Comments/Debates
C2 - 12810101
AN - SCOPUS:0042967963
SN - 1471-4906
VL - 24
SP - 296
EP - 297
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -
