Neutrophils synthesize and activate TGFβ2

Christof H. Szymkowiak, Elena Csernok, Dirk Reinhold, Ute Bank, Wolfgang L. Gross, Jörn Kekow*

*Corresponding author for this work
11 Citations (Scopus)


Human polymorphonuclear neutrophils (PMN) are regulated by soluble factors such as chemotactic peptides and cytokines. PMN themselves are capable of synthesizing and releasing various cytokines, thereby taking part in the afferent or inductive limb of the immune response. We report for the first time that TGFβ2 can be synthesized and released by PMN obtained from peripheral blood. Reverse transcriptase polymerase chain reaction (RT-PCR) showed that preparations of PMN express mRNA for transforming growth factor (TGF)β1 and TGFβ2 but not for TGFβ3. Only translation of TGFβ2 into protein was observed applying different assays. Interestingly, TGFβ2 in supernatants from stimulated PMN could be detected in the bioactive form. (C) 2000 Academic Press.

Original languageEnglish
Issue number4
Pages (from-to)397-400
Number of pages4
Publication statusPublished - 04.2000

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Neutrophils synthesize and activate TGFβ2'. Together they form a unique fingerprint.

Cite this